Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model.

Autor: Costa-Marques L; 1Centre for Biological Engineering, School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough, UK., Arnold K; 2Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany., Pardon MC; School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK., Leovsky C; 2Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany., Swarbrick S; 1Centre for Biological Engineering, School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough, UK., Fabian C; 2Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany., Stolzing A; 1Centre for Biological Engineering, School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough, UK.; 4Leipzig University, Leipzig, Germany.
Jazyk: angličtina
Zdroj: Translational neurodegeneration [Transl Neurodegener] 2019 Oct 14; Vol. 8, pp. 33. Date of Electronic Publication: 2019 Oct 14 (Print Publication: 2019).
DOI: 10.1186/s40035-019-0173-9
Abstrakt: Background: We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice.
Method: BM-M were transplanted into the tail vein and the animals analysed 1 month later.
Results: BM-M transplantation promoted the reduction of the amyloid beta [37 - 42] plaque number and size in the cortex and hippocampus of the treated mice, but no change in the more heavily modified pyroglutamate amyloid beta E3 plaques. The number of phenotypically 'small' microglia increased in the hippocampus. Astrocyte size decreased overall, indicating a reduction of activated astrocytes. Gene expression of interleukin 6 and 10, interferon-gamma, and prostaglandin E receptor 2 was significantly lower in the hippocampus, while interleukin 10 expression was elevated in the cortex of the treated mice.
Conclusions: BM-M systemically transplanted, promote a decrease in neuroinflammation and a limited reversion of amyloid pathology. This exploratory study may support the potential of BM-M or microglia-like cell therapy and further illuminates the mechanisms of action associated with such transplants.
Competing Interests: Competing interestsThe authors declare that they have no competing interests.
(© The Author(s). 2019.)
Databáze: MEDLINE
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