During infant maltreatment, stress targets hippocampus, but stress with mother present targets amygdala and social behavior.

Autor:	Raineki C; Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962; craineki@mail.ubc.ca Maya.Opendak@nyulangone.org mcewen@mail.rockefeller.edu regina.sullivan@nyumc.org.; Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016.; Center for Neural Science, New York University, New York, NY 10003.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Opendak M; Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962; craineki@mail.ubc.ca Maya.Opendak@nyulangone.org mcewen@mail.rockefeller.edu regina.sullivan@nyumc.org.; Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016., Sarro E; Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962.; Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016., Showler A; Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962.; Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016., Bui K; Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962.; Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016., McEwen BS; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10065 craineki@mail.ubc.ca Maya.Opendak@nyulangone.org mcewen@mail.rockefeller.edu regina.sullivan@nyumc.org., Wilson DA; Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962.; Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016.; Center for Neural Science, New York University, New York, NY 10003., Sullivan RM; Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962; craineki@mail.ubc.ca Maya.Opendak@nyulangone.org mcewen@mail.rockefeller.edu regina.sullivan@nyumc.org.; Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016.; Center for Neural Science, New York University, New York, NY 10003.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Nov 05; Vol. 116 (45), pp. 22821-22832. Date of Electronic Publication: 2019 Oct 21.
DOI:	10.1073/pnas.1907170116
Abstrakt:	Infant maltreatment increases vulnerability to physical and mental disorders, yet specific mechanisms embedded within this complex infant experience that induce this vulnerability remain elusive. To define critical features of maltreatment-induced vulnerability, rat pups were reared from postnatal day 8 (PN8) with a maltreating mother, which produced amygdala and hippocampal deficits and decreased social behavior at PN13. Next, we deconstructed the maltreatment experience to reveal sufficient and necessary conditions to induce this phenotype. Social behavior and amygdala deficits (volume, neurogenesis, c-Fos, local field potential) required combined chronic high corticosterone and maternal presence (not maternal behavior). Hippocampal deficits were induced by chronic high corticosterone regardless of social context. Causation was shown by blocking corticosterone during maltreatment and suppressing amygdala activity during social behavior testing. These results highlight (1) that early life maltreatment initiates multiple pathways to pathology, each with distinct causal mechanisms and outcomes, and (2) the importance of social presence on brain development. Competing Interests: The authors declare no competing interest.
Databáze:	MEDLINE
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