| Autor: |
Krupek T; Postgraduate Programs in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná State, Brazil., Ferrari BJW; Postgraduate Programs in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná State, Brazil., Silva MARCPD; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Paraná State, Brazil., Schamber CR; Postgraduate Programs in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná State, Brazil., Bertolini DA; Postgraduate Programs in Health Sciences, State University of Maringá, Maringá, Paraná State, Brazil., Bruschi ML; Postgraduate Programs in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná State, Brazil.; Department of Pharmacy, State University of Maringá, Maringá, Paraná State, Brazil., Previdelli ITS; Postgraduate Programs in Biostatistics, State University of Maringá, Maringá, Paraná State, Brazil., Pereira OCN; Postgraduate Programs in Biostatistics, State University of Maringá, Maringá, Paraná State, Brazil., Dias JRC; Public Service Health Care for Sexually Transmitted Diseases/Aids Center of Maringá City, Maringá, Paraná State, Brazil., Curi R; Interdisciplinary Postgraduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo, São Paulo State, Brazil., Bazotte RB; Postgraduate Programs in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná State, Brazil.; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Paraná State, Brazil. |
| Abstrakt: |
The impact of oral supplementation with an effervescent glutamine formulation on the beneficial effects of antiretroviral therapies was evaluated in people living with HIV/AIDS. For this purpose, 12 HIV/AIDS carrier patients with CD4 + T cell counts <500, and who had received the same antiretroviral therapy for at least 1 year before starting this investigation were selected. The patients were required to dissolve the effervescent glutamine formulation (supplied in sachets) in water immediately before oral ingestion (12.4 g), once a day, after lunch or after dinner during 30 days. CD4 + T cell counts, complete blood cell counts, serum cytokines, and amino acids levels were quantified; biochemical and toxicological measurements were performed. The numbers of CD4 + T cells were increased ( P < .05), and the serum C-reactive protein levels decreased ( P < .01) after the administration of effervescent glutamine formulation. Serum levels of interferon-gamma inducible protein-10, RANTES, and macrophage inflammatory protein-1 β were decreased after the treatment with effervescent glutamine formulation. No changes were observed in the serum levels of amino acids, hematological, toxicological, and biochemical parameters. In conclusion, the treatment during 30 days with effervescent glutamine formulation was well tolerated, promoted reduction of inflammation, and improved the beneficial effects of antiretroviral therapies in HIV/AIDS carrier patients. |
