Different core-specific T cell subsets are expanded in chronic hepatitis C with advanced liver disease.

Autor: Cachem FCOF; Department of Microbiology and Parasitology/Federal University of the State of Rio de Janeiro, Brazil; Department of Microbiology, Immunology and Parasitology, UERJ, Rio de Janeiro, Brazil., Dias AS; Department of Microbiology and Parasitology/Federal University of the State of Rio de Janeiro, Brazil; Department of Microbiology, Immunology and Parasitology, UERJ, Rio de Janeiro, Brazil., Monteiro C; Department of Microbiology and Parasitology/Federal University of the State of Rio de Janeiro, Brazil; Department of Microbiology, Immunology and Parasitology, UERJ, Rio de Janeiro, Brazil., Fernandes G; Department of Microbiology and Parasitology/Federal University of the State of Rio de Janeiro, Brazil., Delphim L; Department of Microbiology and Parasitology/Federal University of the State of Rio de Janeiro, Brazil., Tavares F; Department of Microbiology and Parasitology/Federal University of the State of Rio de Janeiro, Brazil., Maciel AMA; Internal Medicine Department/Division of Gastroenterology & Hepatology, Rio de Janeiro, Brazil., Amendola-Pires MM; Internal Medicine Department/Division of Gastroenterology & Hepatology, Rio de Janeiro, Brazil., Brandão-Mello CE; Internal Medicine Department/Division of Gastroenterology & Hepatology, Rio de Janeiro, Brazil., Andrade RM; Department of General Medicine, HUGG/UNIRIO, Rio de Janeiro, Brazil., Bento CAM; Department of Microbiology and Parasitology/Federal University of the State of Rio de Janeiro, Brazil; Department of Microbiology, Immunology and Parasitology, UERJ, Rio de Janeiro, Brazil. Electronic address: cbento@globo.com.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2019 Dec; Vol. 124, pp. 154456. Date of Electronic Publication: 2018 Jun 28.
DOI: 10.1016/j.cyto.2018.06.023
Abstrakt: Chronic hepatitis C (CHC) is frequently related to liver fibrosis, and several studies have suggested that the immunological activity of HCV antigens contributes to hepatic damage. In the present study, among structural and non-structural HCV antigens, elevatedIL-1β, IL-6, IL-17 levels were secreted by PBMC cultures obtained from CHC patients following stimulation with core antigen. Moreover, the percentage of core-specific IL-6 + IL-17 + (CD4 + and CD8 + ) T cells was significantly higher in patients with worsehepatic lesions, determined on the Metavir scale. When compared with healthy subjects, the percentage of circulating Treg cells was elevated in CHC patients, mainly among those with advanced liver fibrosis. Nevertheless, in this last group of patients, the proportion of CD39 + Treg subsets was very low. Finally, the percentage of senescent (CD57 + CD28 - ) and exhausted (PD-1 + CD28 + ) core-specific T cells in CHC patients was also found to be a result of fibrotic hepatic status. In summary, imbalances between different core-specific T cell subsets are associated with liver fibrosis severity.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: