| Autor: |
Suplotova LA, Khramova YВ, Makarova ОВ, Yuzhakova NY, Barkova TV, Mikhalchuk VV |
| Jazyk: |
ruština |
| Zdroj: |
Problemy endokrinologii [Probl Endokrinol (Mosk)] 2006 Aug 15; Vol. 52 (4), pp. 31-34. Date of Electronic Publication: 2006 Aug 15. |
| DOI: |
10.14341/probl200652431-34 |
| Abstrakt: |
The study was undertaken to evaluate the efficiency of the 2003-2004 neonatal screening for congenital adrenal hyperplasia (САН) in Tyumen and to estimate the prevalence of classical forms of 21-OH deficiency in the newborns by the results of the screening. Neonatal 17-OHP levels were determined in 20,011 neonatal infants by bilateral enzyme-linked immunosorbent assay (ELISA) at a sensitivity of 0.13 n/mol/l, by using "Delfia Neonatal 17-OHP" kits. In 124 (0.61%), the level of 17-OHP was greater than 60 nmol/l; retests identified 2 babies with salt-loosing САН. Thus, the Incidence of classical forms of САН was 1:10,005 in the Tyumen population. In low-weight premature infants, 17-OHP levels were significantly higher than those in full-term or normal-weight babies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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