HIV-1 Replication Benefits from the RNA Epitranscriptomic Code.

Autor: Kong W; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA; Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, 94158, USA. Electronic address: weili.kong@gladstone.ucsf.edu., Rivera-Serrano EE; Department of Microbiology and Molecular Genetics, University of California, Davis, CA, 95616, USA., Neidleman JA; Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, 94158, USA., Zhu J; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. Electronic address: jian.zhu@osumc.edu.
Jazyk: angličtina
Zdroj: Journal of molecular biology [J Mol Biol] 2019 Dec 06; Vol. 431 (24), pp. 5032-5038. Date of Electronic Publication: 2019 Oct 15.
DOI: 10.1016/j.jmb.2019.09.021
Abstrakt: The effects of RNA methylation on HIV-1 replication remain largely unknown. Recent studies have discovered new insights into the effect of 2'-O-methylation and 5-methylcytidine marks on the HIV-1 RNA genome. As so far, HIV-1 benefits from diverse RNA methylations through distinct mechanisms. In this review, we summarize the recent advances in this emerging field and discuss the role of RNA methylation writers and readers in HIV-1 infection, which may help to find alternative strategies to control HIV-1 infection.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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