Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.

Autor: Kolik LG; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. lgkolik@mail.ru., Nadorova AV; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Antipova TA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Kruglov SV; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Kudrin VS; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Durnev AD; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Sep; Vol. 167 (5), pp. 641-644. Date of Electronic Publication: 2019 Oct 17.
DOI: 10.1007/s10517-019-04588-9
Abstrakt: The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks. In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal. In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05). These results indicate positive effects of the tuftsin analogue on age-related memory disturbances associated with chronic alcohol intoxication and confirm the involvement of the neurotrophin mechanism related to BDNF production into the effect of Selank.
Databáze: MEDLINE
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