Oral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: A molecular and bioinformatic approach.

Autor: Paraíso AF; Departament of Nursing, Faculdades Santo Agostinho, Montes Claros, Minas Gerais, Brazil; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil., Sousa JN; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil., Andrade JMO; Departament of Nursing, Faculdades Santo Agostinho, Montes Claros, Minas Gerais, Brazil; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil., Mangabeira ES; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil., Lelis DF; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil., de Paula AMB; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil., Martins AMEB; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil., Lima WJN; Institute of Agricultural Sciences (ICA), Food Engineering, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Guimarães ALS; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil., Melo GA; Postgraduate Program in Biology, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil., Schwarz M; Department of Transplantation Surgery and Section for Surgical Research, Medical University of Graz, Austria., Santos SHS; Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil; Institute of Agricultural Sciences (ICA), Food Engineering, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: sergiosousas@hotmail.com.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2019 Nov 15; Vol. 237, pp. 116914. Date of Electronic Publication: 2019 Oct 14.
DOI: 10.1016/j.lfs.2019.116914
Abstrakt: Aims: The aim of the presente study was to examine the effects of oral gallic acid (GA) administration on the brown adipose tissue of obese mice fed with high-fat diet. New mechanisms and interactions pathways in thermogenesis were accessed through bioinformatics analyses.
Main Methods: Swiss male mice were divided into four groups and fed during 60 days with: standard diet, standard diet combined with gallic acid, high-fat diet and high-fat diet combined with gallic acid. Body weight, food intake, and blood parameters (glucose tolerance test, total-cholesterol, high-density low-c, triglyceride and glucose levels) were evaluated. Brown and subcutaneous white adipose tissue histological analysis were performed. SIRT1 and PGC1-α mRNA expression in the brown adipose tissue were assessed.
Key Findings: Our main findings showed that the gallic acid improved glucose tolerance and metabolic parameters. These results were accompanied by bioinformatics analyses that evidenced SIRT1 as main target in the thermogenesis process, confirmed as increased SIRT1 mRNA expression was evidenced in the brown adipose tissue.
Significance: Together, the data suggest that the gallic acid effect in brown adipose tissue may improve body metabolism, glucose homeostasis and increase thermogenesis.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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