BRAIN Initiative: Cutting-Edge Tools and Resources for the Community.

Autor:	Litvina E; National Institutes of Health, Bethesda, Maryland 20892., Adams A; National Institutes of Health, Bethesda, Maryland 20892., Barth A; Carnegie Mellon University, Pittsburgh, Pennsylvania 15213., Bruchez M; Carnegie Mellon University, Pittsburgh, Pennsylvania 15213., Carson J; The University of Texas at Austin, Austin, Texas 78712., Chung JE; Medical Scientist Training Program and Neuroscience Graduate Program.; Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, California 94158., Dupre KB; National Institutes of Health, Bethesda, Maryland 20892., Frank LM; Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, California 94158.; Howard Hughes Medical Institute, San Francisco, California 94143., Gates KM; University of North Carolina, Chapel Hill, North Carolina 27753., Harris KM; The University of Texas at Austin, Austin, Texas 78712., Joo H; Medical Scientist Training Program and Neuroscience Graduate Program.; Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, California 94158., William Lichtman J; Harvard University, Cambridge MA 02138., Ramos KM; National Institutes of Health, Bethesda, Maryland 20892., Sejnowski T; University of California, San Diego, La Jolla, California 92093.; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, and., Trimmer JS; University of California, Davis, Davis CA 95616., White S; National Institutes of Health, Bethesda, Maryland 20892., Koroshetz W; National Institutes of Health, Bethesda, Maryland 20892, koroshetzw@ninds.nih.gov.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2019 Oct 16; Vol. 39 (42), pp. 8275-8284.
DOI:	10.1523/JNEUROSCI.1169-19.2019
Abstrakt:	The overarching goal of the NIH BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative is to advance the understanding of healthy and diseased brain circuit function through technological innovation. Core principles for this goal include the validation and dissemination of the myriad innovative technologies, tools, methods, and resources emerging from BRAIN-funded research. Innovators, BRAIN funding agencies, and non-Federal partners are working together to develop strategies for making these products usable, available, and accessible to the scientific community. Here, we describe several early strategies for supporting the dissemination of BRAIN technologies. We aim to invigorate a dialogue with the neuroscience research and funding community, interdisciplinary collaborators, and trainees about the existing and future opportunities for cultivating groundbreaking research products into mature, integrated, and adaptable research systems. Along with the accompanying Society for Neuroscience 2019 Mini-Symposium, "BRAIN Initiative: Cutting-Edge Tools and Resources for the Community," we spotlight the work of several BRAIN investigator teams who are making progress toward providing tools, technologies, and services for the neuroscience community. These tools access neural circuits at multiple levels of analysis, from subcellular composition to brain-wide network connectivity, including the following: integrated systems for EM- and florescence-based connectomics, advances in immunolabeling capabilities, and resources for recording and analyzing functional connectivity. Investigators describe how the resources they provide to the community will contribute to achieving the goals of the NIH BRAIN Initiative. Finally, in addition to celebrating the contributions of these BRAIN-funded investigators, the Mini-Symposium will illustrate the broader diversity of BRAIN Initiative investments in cutting-edge technologies and resources. (Copyright © 2019 the authors.)
Databáze:	MEDLINE
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