Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture.
| Autor: | Chandler DJ; Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, New Jersey 08084., Jensen P; Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709., McCall JG; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110, Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, Missouri 63110, Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, Missouri 63110, and Washington University Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110., Pickering AE; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.; Bristol Anaesthesia, Pain and Critical Care Sciences, Translational Health Sciences, Bristol Medical School, Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom., Schwarz LA; St. Jude Children's Research Hospital, Memphis, Tennessee 38105., Totah NK; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany 72076, nelson.totah@tuebingen.mpg.de.; Helsinki Institute of Life Science, Helsinki 00014, Finland, and.; School of Pharmacy, University of Helsinki, Helsinki 00014, Finland. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2019 Oct 16; Vol. 39 (42), pp. 8239-8249. |
| DOI: | 10.1523/JNEUROSCI.1164-19.2019 |
| Abstrakt: | The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus that is a prominent component of disparate theories of brain function due to its broad noradrenergic projections throughout the CNS. As a diffuse neuromodulatory system, noradrenaline affects learning and decision making, control of sleep and wakefulness, sensory salience including pain, and the physiology of correlated forebrain activity (ensembles and networks) and brain hemodynamic responses. However, our understanding of the LC is undergoing a dramatic shift due to the application of state-of-the-art methods that reveal a nucleus of many modules that provide targeted neuromodulation. Here, we review the evidence supporting a modular LC based on multiple levels of observation (developmental, genetic, molecular, anatomical, and neurophysiological). We suggest that the concept of the LC as a singular nucleus and, alongside it, the role of the LC in diverse theories of brain function must be reconsidered. (Copyright © 2019 the authors.) |
| Databáze: | MEDLINE |
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