Convergent Projections from Perirhinal and Postrhinal Cortices Suggest a Multisensory Nature of Lateral, but Not Medial, Entorhinal Cortex.

Autor:	Doan TP; Kavli Institute for Systems Neuroscience, Centre for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU Norwegian University of Science and Technology, Trondheim, Norway., Lagartos-Donate MJ; Kavli Institute for Systems Neuroscience, Centre for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU Norwegian University of Science and Technology, Trondheim, Norway., Nilssen ES; Kavli Institute for Systems Neuroscience, Centre for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU Norwegian University of Science and Technology, Trondheim, Norway., Ohara S; Laboratory of Systems Neuroscience, Tohoku University Graduate School of Life Science, Sendai, Japan., Witter MP; Kavli Institute for Systems Neuroscience, Centre for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: menno.witter@ntnu.no.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2019 Oct 15; Vol. 29 (3), pp. 617-627.e7.
DOI:	10.1016/j.celrep.2019.09.005
Abstrakt:	The current model of the organization of the medial temporal lobe (MTL) episodic memory system assumes that two functionally different "where" and "what" pathways enter MTL as parallel parahippocampal cortex (PHC)-medial entorhinal cortex (MEC) and perirhinal cortex (PER)-lateral entorhinal cortex (LEC) streams, respectively. With the use of tract tracing and in vitro electrophysiological recordings, we show that, in the rat LEC, all main principal neuron types in layer II receive convergent inputs from PER and postrhinal cortex (POR), homologous to PHC in primates. Projections to MEC from POR are much less prominent than previously assumed. These findings thus challenge the prevailing concept that LEC and MEC are defined by different inputs from the PER and PHC/POR, respectively. Our findings point to LEC as the main parahippocampal multimodal integrative structure whose unique set of external sensory-derived inputs allows its network to represent a continuously fluctuating extrinsic environment. (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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