Ointments containing Ceratothoa oestroides extract: Evaluation of their healing potential in the treatment of diabetic foot ulcers.

Autor: Meimeti E; Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou, National and Kapodistrian University of Athens, Athens, Greece., Tentolouris N; National and Kapodistrian University of Athens, 1st Department of Propaedeutic Internal Medicine, Medical School, Laiko General Hospital, Athens, Greece., Manes C; Diabetic Foot Department, General Hospital of Thessaloniki Papageorgiou, Thessaloniki, Greece., Loupa C; Demetrios Voyatzoglou Diabetic Foot Clinic, A. Fleming Hospital, Athens, Greece., Provatopoulou X; Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou, National and Kapodistrian University of Athens, Athens, Greece., Mostratos D; Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou, National and Kapodistrian University of Athens, Athens, Greece., Vitsos A; Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou, National and Kapodistrian University of Athens, Athens, Greece., Roussis V; Department of Pharmacy, Section of Pharmacognosy and Chemistry of Natural Products, Panepistimiopolis Zografou, National and Kapodistrian University of Athens, Athens, Greece., Tzouvelekis L; National and Kapodistrian University of Athens, Department of Microbiology, Medical School, University of Athens, Athens, Greece., Miriagou V; Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens, Greece., Rallis M; Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou, National and Kapodistrian University of Athens, Athens, Greece.
Jazyk: angličtina
Zdroj: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society [Wound Repair Regen] 2020 Mar; Vol. 28 (2), pp. 234-241. Date of Electronic Publication: 2019 Nov 27.
DOI: 10.1111/wrr.12771
Abstrakt: Diabetic foot ulceration is a common and severe complication of diabetes, causing substantial social, medical, and economic burdens. Treatment of foot ulcers remains challenging, thus requiring increasing awareness and more efficient management. This study investigates the efficacy of ointments, containing as main active ingredient the olive oil extract of the marine isopod Ceratothoa oestroides, in the treatment of patients with diabetic foot ulcers. Fifty-two patients were allocated into four treatment groups either receiving therapy with an ointment containing extract of C. oestroides or extract of C. oestroides and eosin or extract of C. oestroides and cefaclor or no treatment. Patients were monitored for a period of 135 days by evaluation of transepidermal water loss, skin hydration, planimetry, photo-documentation, and clinical condition. Treatment with the extract of C. oestroides demonstrated significant healing properties that became evident after 45 days of treatment and resulted in complete ulcer healing in 61% of the patients. A significant improvement in transepidermal water loss (p < 0.001), skin hydration levels (p < 0.001), and wound area (p < 0.001) was observed in all patients. Similar efficacy was demonstrated for the combination of C. oestroides extract with eosin treatment (p < 0.001). On the contrary, the combination of C. oestroides extract with cefaclor antibiotic agent completely inhibited the healing properties of the isopod extract and did not improve water loss, skin hydration, or wound area. An important factor for C. oestroides extract healing properties is its selective activity against Gram negative bacteria. Ointments containing C. oestroides extract alone or combined with the antimicrobial agent eosin emerges as an effective regimen for the treatment of diabetic foot ulcers.
(© 2019 by the Wound Healing Society.)
Databáze: MEDLINE
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