Electrochemical determination of the antipsychotic medication clozapine by a carbon paste electrode modified with a nanostructure prepared from titania nanoparticles and copper oxide.

Autor: Ghanbari MH; Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, 19516-83759, Iran.; Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, 19516-83759, Iran.; Faculty of Chemistry, Kharazmi University, Tehran, 15719-14911, Iran., Shahdost-Fard F; Department of Chemistry, University of Ilam, Ilam, 69315-45516, Iran.; Faculty of Medicine, Ilam University of Medical Sciences, Ilam, 69391-77143, Iran., Rostami M; Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, 16987-39196, Iran., Khoshroo A; Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 67346-67149, Iran., Sobhani-Nasab A; Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, 87196-57891, Iran.; Core Research Lab, Kashan University of Medical Sciences, Kashan, 87196-57891, Iran., Gholipour N; Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, 19516-83759, Iran.; Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, 19516-83759, Iran., Salehzadeh H; Faculty of Chemistry, Kharazmi University, Tehran, 15719-14911, Iran., Ganjali MR; Center of Excellence in Electrochemistry, University of Tehran, Tehran, 19839-69411, Iran.; Biosensor Research Centre, Endocrinology & Metabolism Molecular and Cellular Research Institute, Tehran University of Medical Sciences, Tehran, 19839-69411, Iran., Rahimi-Nasrabadi M; Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, 19516-83759, Iran. rahiminasrabadi@gmail.com.; Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, 19516-83759, Iran. rahiminasrabadi@gmail.com., Ahmadi F; Physiology Research Center, Iran University of Medical Sciences, Tehran, 14496-14535, Iran. Farhadahmadi55@gmail.com.; Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, 14515-55763, Iran. Farhadahmadi55@gmail.com.
Jazyk: angličtina
Zdroj: Mikrochimica acta [Mikrochim Acta] 2019 Oct 15; Vol. 186 (11), pp. 698. Date of Electronic Publication: 2019 Oct 15.
DOI: 10.1007/s00604-019-3760-7
Abstrakt: A nanostructure was prepared from titania nanoparticles and copper oxide (TiO 2 NP@CuO) and used to modify a carbon paste electrode (CPE). The modified CPE is shown to enable sensitive voltammetric determination of the drug clozapine (CLZ). The sensor was characterized by various techniques and some key parameters were optimized. Under the optimum conditions and at a working potential of 0.6 V (vs. Ag/AgCl), the modified CPE has two linear response ranges, one from 30 pmol L -1 to 4 nmol L -1 of CLZ, the other from 4 nmol L -1 to 10 μmol L -1 . The detection limit is as low as 9 pM. The transfer coefficient (α) and catalytic rate constant (k cat ) were calculated and the reliability of the sensor was estimated for CLZ sensing in real samples where it gave satisfactory results. Graphical abstract Applicability of the TiO 2 NP@CuO nanostructures in fabrication of an efficient clozapine (CLZ) sensor based on the use of a carbon paste electrode.
Databáze: MEDLINE
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