Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy.

Autor:	Byvaltsev VA; Neurosurgery and Innovative Medicine Department, Irkutsk State Medical University, Irkutsk, Russia.; Irkutsk Scientific Center of Surgery and Traumatology, Irkutsk, Russia., Bardonova LA; Neurosurgery and Innovative Medicine Department, Irkutsk State Medical University, Irkutsk, Russia., Onaka NR; University of Arizona College of Medicine, Phoenix, AZ, United States., Polkin RA; Neurosurgery and Innovative Medicine Department, Irkutsk State Medical University, Irkutsk, Russia., Ochkal SV; Neurosurgery and Innovative Medicine Department, Irkutsk State Medical University, Irkutsk, Russia., Shepelev VV; Neurosurgery and Innovative Medicine Department, Irkutsk State Medical University, Irkutsk, Russia., Aliyev MA; Neurosurgery and Innovative Medicine Department, Irkutsk State Medical University, Irkutsk, Russia., Potapov AA; Federal State Autonomous Institution 'N. N. Burdenko National Scientific and Practical Center for Neurosurgery' of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2019 Sep 24; Vol. 9, pp. 925. Date of Electronic Publication: 2019 Sep 24 (Print Publication: 2019).
DOI:	10.3389/fonc.2019.00925
Abstrakt:	Introduction: Acridine orange (AO) was first extracted from coal tar in the late nineteenth century and was used as a fluorescent dye. In this paper, we review emergent research about novel applications of AO for fluorescence surgery and cancer therapy. Materials and methods: We performed a systematic search in the MEDLINE, PubMed, Cochrane library, Google Scholar, Embase, Web of Science, and Scopus database using combinations of the term "acridine orange" with the following: "surgical oncology," "neuropathology," "microsurgery," "intraoperative fluorescence," "confocal microscopy," "pathology," "endomicroscopy," "guidance," "fluorescence guidance," "oncology," "surgery," "neurooncology," and "photodynamic therapy." Peer-reviewed articles published in English were included in this review. We have also scanned references for relevant articles. Results: We have reviewed studies on the various application of AO in microscopy, endomicroscopy, intraoperative fluorescence guidance, photodynamic therapy, sonodynamic therapy, radiodynamic therapy. Conclusion: Although the number of studies on the clinical use of AO is limited, pilot studies have demonstrated the safety and feasibility of its application as an intraoperative fluorescent dye and as a novel photo- and radio-sensitizator. Further clinical studies are necessary to more definitively assess the clinical benefit AO-based fluorescence guidance, therapy for sarcomas, and to establish feasibility of this new approach for the treatment of other tumor types. (Copyright © 2019 Byvaltsev, Bardonova, Onaka, Polkin, Ochkal, Shepelev, Aliyev and Potapov.)
Databáze:	MEDLINE
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