| Autor: |
Dell'Osso B; Department of Biomedical and Clinical Sciences 'Luigi Sacco'.; Department of Mental Health, ASST Fatebenefratelli-Sacco, Università degli Studi di Milano.; 'Aldo Ravelli' Research Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, University of Milan Medical School, Milan, Italy.; Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA., Cremaschi L; Department of Biomedical and Clinical Sciences 'Luigi Sacco'.; Department of Mental Health, ASST Fatebenefratelli-Sacco, Università degli Studi di Milano., Arici C; Department of Biomedical and Clinical Sciences 'Luigi Sacco'.; Department of Mental Health, ASST Fatebenefratelli-Sacco, Università degli Studi di Milano., Altamura AC; Department of Biomedical and Clinical Sciences 'Luigi Sacco'.; Department of Mental Health, ASST Fatebenefratelli-Sacco, Università degli Studi di Milano., Hooshmand F; Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA., Do D; Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA., Shah S; Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA., Gershon A; Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA., Holsinger A; Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA., Yeon Park D; Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea., Miller S; Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA., Wang PW; Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA., Ketter TA; Department of Psychiatry and Behavioral Sciences, Stanford University, California, USA. |
| Abstrakt: |
Assess bipolar disorder subtype and treatment location effects on bipolar disorder core pharmacotherapy. Outpatients not in a syndromal episode referred to the University of Milan and Stanford University Bipolar Disorder Clinics were assessed with SCID for the fourth Edition of the Diagnostic and Statistical Manual of Mood Disorders, and the Systematic Treatment Enhancement Program for Bipolar Disorder Affective Disorders Evaluation, respectively. Prevalence and clinical correlates of antidepressant, antipsychotic, and mood stabilizer use, in aggregate and individually, were compared in bipolar I (BDI) versus II (BDII) patients in Milan/Stanford and in Milan versus Stanford patients, stratified by subtype. Milan/Stanford pooled BDI versus BDII patients significantly more often took antipsychotic (69.8 versus 44.8%), mood stabilizers (68.6 versus 57.7%), and valproate (40.1 versus 17.5%), and less often took antidepressants (23.1 versus 55.6%) and lamotrigine (9.9 versus 25.2%). Milan versus Stanford patients (stratified by bipolar disorder subtype) significantly more often took antipsychotic (BDI and BDII), antidepressants (BDII), and valproate (BDII), and less often took lamotrigine (BDI). Research regarding bipolar disorder core pharmacotherapy relationships with bipolar subtype and treatment location is warranted to enhance clinical management. |
