Combined treatment of hidradenitis suppurativa with intense pulsed light (IPL) and radiofrequency (RF).

Autor: Wilden S; Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany., Friis M; Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany., Tuettenberg A; Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany., Staubach-Renz P; Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany., Wegner J; Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany., Grabbe S; Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany., von Stebut E; Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany.; Department of Dermatology, Faculty of Medicine, University of Cologne, Cologne, Germany.
Jazyk: angličtina
Zdroj: The Journal of dermatological treatment [J Dermatolog Treat] 2021 Aug; Vol. 32 (5), pp. 530-537. Date of Electronic Publication: 2019 Oct 17.
DOI: 10.1080/09546634.2019.1677842
Abstrakt: Background: Hidradenitis suppurativa is a chronic inflammatory disease with high burden. Treatment options are often unsatisfactory. We assessed the effect of a combination therapy of intense pulsed light (IPL) and radiofrequency (RF).
Methods: The explorative study included 47 patients and was performed as a prospective, monocentric, randomized, three-arm parallel-group design trial with a prior 12 weeks observation period. Treatment arms were IPL and RF monotherapies or IPL + RF combination therapy. After 12 weeks, all patients received IPL + RF for additional 12 weeks (cross-over). Primary endpoint was the change in active lesion numbers, secondary endpoint the change in Dermatology Quality of Life Index (DLQI).
Results: After 12 weeks, active lesion counts of the IPL + RF group decreased more than in the IPL group ( p  = .044); the decrease in DLQI was significantly higher in the IPL + RF and RF groups compared to IPL. Prolonged 24-week treatment with IPL + RF obtained better results as 12 weeks. Overall, disease burden after 24 weeks of treatment compared to disease fluctuation during the observation period was significantly lower (change in active lesions -3.6, p  = .001; in DLQI -5.2, p  = .003).
Conclusions: IPL + RF treatment appears to represent a promising therapeutic option that leads to reduction of disease activity without severe side effects.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje