Antidiabetic and antioxidant effects of tannic acid and melatonin on streptozotocin induced diabetes in rats.

Autor:	Esmaie EM; Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, Egypt., Abo-Youssef AM; Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, Egypt., Tohamy MA; Department of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef, Egypt.
Jazyk:	angličtina
Zdroj:	Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2019 Jul; Vol. 32 (4), pp. 1453-1459.
Abstrakt:	The present investigation aimed to study the possible antidiabetic and related antioxidant potentials of tannic acid and melatonin in streptozotocin (STZ) induced diabetes in rats. Four groups of rats received intraperitoneal one dose of 50mg/kg body weight STZ for the induction of diabetes. The first group served as diabetic control group and received the vehicle. Four days after induction of diabetes, the remaining three groups received glibenclamide (6mg/kg/day), tannic acid (1 g/kg/day) and melatonin (10 mg/kg/day) for two weeks. A fifth group served as vehicle control group. At the end of the experimental period, blood samples and liver samples were collected for the determination of diabetes correlated biomarkers. Treatment of diabetic rats with tannic acid or melatonin attenuated most of the changes associated with STZ induced diabetes. The present results evidenced the beneficial effects of tannic acid and melatonin in diabetes management.
Databáze:	MEDLINE
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