Somatic copy number alterations in pleomorphic adenoma and recurrent pleomorphic adenoma.

Autor: Mariano FV; Pathology Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil. Electronic address: fevimariano@gmail.com., Fidalgo F; International Research Center, AC Camargo Cancer Center, São Paulo-SP, Brazil., Casarim ALM; Head and Neck Surgery Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil., Martins AS; Head and Neck Surgery Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil., Scarini JF; Oral Pathology Department, Piracicaba Dental School/UNICAMP, Piracicaba-SP, Brazil., de Lima Souza RA; Oral Pathology Department, Piracicaba Dental School/UNICAMP, Piracicaba-SP, Brazil., Egal ES; Pathology Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil., Kowalski LP; Head and Neck Surgery Department, AC Camargo Cancer Center, São Paulo-SP, Brazil., Krepischi ACV; Department of Genetics and Evolutionary Biology, Institute of Biosciences, USP, São Paulo-SP, Brazil., Altemani A; Pathology Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2020 Jan; Vol. 129 (1), pp. 59-64. Date of Electronic Publication: 2019 Sep 02.
DOI: 10.1016/j.oooo.2019.08.016
Abstrakt: Objective: As the genetic changes in recurrent pleomorphic adenoma (RPA) have not yet been investigated, the aim of this study was to assess the genomic profile of somatic copy number alteration in RPA and pleomorphic adenoma (PA) by using array comparative genomic hybridization (aCGH).
Study Design: Four cases of RPA and 13 cases of PA were evaluated by using aCGH, using a 180 K platform. Data were analyzed by using Nexus Copy Number Discovery.
Results: The RPA group rarely showed any copy number alteration, except for 1 case that exhibited losses in 5 p15.33 p15.1, 5 q13.1 q35.3 and 12 q12 q13.11. The PA group also showed few copy number alterations, and the most frequent findings involved chromosomes 8: 8p21.3-p12 (gain), 8q12.1 (loss), 8p23.3-q24.3 (gain), and 8q12.1-q21.11 (gain). Genomic amplifications were revealed in the PA group, and the relevant affected genes were MAML2 and LIFR.
Conclusions: PA and RPA exhibit few somatic copy number alterations and show a similar genomic profile on aCGH.
(Copyright © 2019. Published by Elsevier Inc.)
Databáze: MEDLINE
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