The Influence of Sex Differences on Cardiopulmonary Exercise Metrics Following Heart Transplant.

Autor: Uithoven KE; School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: nyber131@umn.edu., Smith JR; Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Medina-Inojosa JR; Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Squires RW; Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Van Iterson EH; Section of Preventive Cardiology and Rehabilitation, Cleveland Clinic, Cleveland, Ohio, USA., Olson TP; Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Jazyk: angličtina
Zdroj: The Canadian journal of cardiology [Can J Cardiol] 2020 Jan; Vol. 36 (1), pp. 54-59. Date of Electronic Publication: 2019 May 25.
DOI: 10.1016/j.cjca.2019.05.023
Abstrakt: Background: Previous work has shown sex-related differences in cardiopulmonary responses in patients with heart failure (HF); however, sex differences following heart transplant (HTx) have not been examined. Thus, we hypothesized women would demonstrate lower peak oxygen uptake (VO 2peak ) but similar ventilatory efficiency (V E /VCO 2 slope) compared with men prior to HTx. Furthermore, we hypothesized that, following HTx, women would exhibit greater improvements in VO 2peak and V E /VCO 2 slope compared with men.
Methods: HTx patients with cardiopulmonary exercise testing (CPET) between 2007 and 2016 were included. Pre-HTx CPET occurred within 24 months pre-HTx with post-HTx CPET within 12 months following HTx. VO 2peak was measured via standard protocol. V E /VCO 2 slope was calculated using rest-peak ventilation (V E ) and carbon dioxide production (VCO 2 ).
Results: Eighty-eight patients (Men [M]: n = 63, age: 55 ± 12 years; Women [W]: n = 25, age: 47 ± 11 years) were assessed. Pre-HTx VO 2peak (M: 13.9 ± 5.0 vs W: 11.6 ± 3.9 mL/kg/min, P = 0.17) and V E /VCO 2 slope (M: 42 ± 12 vs W: 46 ± 18, P = 0.53) were not different between sexes. Overall, VO 2peak (Pre: 13.3 ± 4.8 vs Post: 18.4 ± 4.8 mL/kg/min, P < 0.01) and V E /VCO 2 slope (Pre: 43 ± 14 vs Post: 37 ± 6, P = 0.02) improved following HTx. Post-VO 2peak (M: 19.0 ± 4.8 vs W: 16.8 ± 4.5 mL/kg/min, P = 0.24) and V E /VCO 2 slope (M: 37 ± 6 vs W: 37 ± 7, P = 0.99) and delta VO 2peak (M: 5.0 ± 4.8 vs W: 5.3 ± 4.9 mL/kg/min, P = 0.85) and V E /VCO 2 slope (M: -5 ± 11 vs W: -9 ± 17, P = 0.29) were not different between sexes.
Conclusions: These data demonstrate that cardiopulmonary improvements following HTx patients occur for both sexes. Importantly, women show similar significant functional improvements following HTx compared with men.
(Copyright © 2019 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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