Later puberty onset among chronically undernourished adolescents living in a Karachi slum, Pakistan.

Autor: Campisi SC; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Peter Gilgan Centre for Research and Learning (PGCRL), Center for Global Child Health, Hospital for Sick Children, Toronto, ON, Canada., Humayun KN; Centre of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan., Rizvi A; Centre of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan., Lou W; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Söder O; Department of Women's and Children's Health, Karolinska Institutet, Widerströmska Huset, Karolinska University Hospital Solna, Stockholm, Sweden., Bhutta ZA; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Peter Gilgan Centre for Research and Learning (PGCRL), Center for Global Child Health, Hospital for Sick Children, Toronto, ON, Canada.; Centre of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2020 May; Vol. 109 (5), pp. 1019-1025. Date of Electronic Publication: 2019 Oct 30.
DOI: 10.1111/apa.15053
Abstrakt: Aim: To assess factors associated with the timing of puberty onset (Tanner Stage Breast 2/Genital 2) among adolescents living in an urban slum in Karachi, Pakistan.
Methods: Girls enrolled at 8-10 years (n = 1009) and boys 9-11 years (n = 863) were followed every 6 months from 2006 to 2010. Parametric survival analysis for interval-censored data was used to estimate median age at puberty onset and assess the association between exposures and timing of puberty onset.
Results: The overall median age at Tanner Stage Breast 2 (AAB2) was 10.1 years (95% CI: 10.1; 10.5), and the median age at Tanner Stage Genital 2 (AAG2) was 10.1 years (95% CI: 10.1; 10.6). Stunting delayed AAB2 1 year and AAG2 about 6 months when compared to non-stunted peers. In the multivariable model, after adjusting for age at enrolment, stunting, thinness and vitamin A deficiency (VAD) were significantly associated with delayed AAB2, while stunting and anaemia were significantly associated with delayed AAG2.
Conclusion: Among adolescents living in the Karachi slum, stunting and highly prevalent anaemia delayed AAG2, while stunting, thinness and VAD delayed AAG2. Parental and household factors were not significantly associated with the timing of puberty onset.
(© 2019 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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