Effectiveness of Phenolic Antioxidants in Experimental Model of Benign Prostatic Hyperplasia.

Autor: Borovskaya TG; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia. repropharm@yandex.ru., Kamalova SI; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia., Grigor'eva VA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia., Poluektova ME; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia., Vychuzhanina AV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia., Kuchin AV; Institute of Chemistry, Komi Scientific Center, Ural Division of Russian Academy of Sciences, Syktyvkar, Russia., Chukicheva IY; Institute of Chemistry, Komi Scientific Center, Ural Division of Russian Academy of Sciences, Syktyvkar, Russia., Buravlev EV; Institute of Chemistry, Komi Scientific Center, Ural Division of Russian Academy of Sciences, Syktyvkar, Russia., Fomina TI; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia., Plotnikov MB; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia., Goldberg VE; Research Institute of Oncology, Tomsk National Research Medical Center, Tomsk, Russia., Dygai AM; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Sep; Vol. 167 (5), pp. 606-609. Date of Electronic Publication: 2019 Oct 12.
DOI: 10.1007/s10517-019-04580-3
Abstrakt: Experimental model of sulpiride-provoked benign prostatic hyperplasia was employed to comparatively assess the effect of phenolic antioxidants (dihydroquercetin, p-thyrozol, dibornol, and prostagenin) on prostate morphology. All examined agents decreased the degree of hyperplasia in acinar epithelium; the greatest efficacy was demonstrated by prostagenin. Moreover, dihydroquercetin and p-thyrozol increased the cross-section area of acinar lumina and prostate volume, which is inadmissible in this pathology. These results suggest that the use of phenolic antioxidants in the therapy of benign prostatic hyperplasia should be strictly controlled.
Databáze: MEDLINE
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