The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3.

Autor: Kuang Z; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wang Y; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Li Y; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Ye C; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Ruhn KA; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Behrendt CL; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Olson EN; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hooper LV; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. lora.hooper@utsouthwestern.edu.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2019 Sep 27; Vol. 365 (6460), pp. 1428-1434.
DOI: 10.1126/science.aaw3134
Abstrakt: Circadian rhythmicity is a defining feature of mammalian metabolism that synchronizes metabolic processes to day-night light cycles. Here, we show that the intestinal microbiota programs diurnal metabolic rhythms in the mouse small intestine through histone deacetylase 3 (HDAC3). The microbiota induced expression of intestinal epithelial HDAC3, which was recruited rhythmically to chromatin, and produced synchronized diurnal oscillations in histone acetylation, metabolic gene expression, and nutrient uptake. HDAC3 also functioned noncanonically to coactivate estrogen-related receptor α, inducing microbiota-dependent rhythmic transcription of the lipid transporter gene Cd36 and promoting lipid absorption and diet-induced obesity. Our findings reveal that HDAC3 integrates microbial and circadian cues for regulation of diurnal metabolic rhythms and pinpoint a key mechanism by which the microbiota controls host metabolism.
(Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze: MEDLINE
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