Ethnic and racial disparities of pancreatic adenocarcinoma in Florida.

Autor:	Fagenson AM; Temple University Hospital, Philadelphia, PA, United States; Florida International University, Miami, FL, United States. Electronic address: Alexander.fagenson@tuhs.temple.edu., Grossi SM; Loma Linda University, Loma Linda, CA, United States; Florida International University, Miami, FL, United States., Musgrove K; Florida International University, Miami, FL, United States; West Virginia University, Morgantown, WV, United States., Solomon N; Loma Linda University, Loma Linda, CA, United States., de la Vega PR; Florida International University, Miami, FL, United States., Castro G; Florida International University, Miami, FL, United States., Pitt HA; Temple University Hospital, Philadelphia, PA, United States., Varella M; Florida International University, Miami, FL, United States., Zavallos J; Florida International University, Miami, FL, United States., Acuna J; Florida International University, Miami, FL, United States.
Jazyk:	angličtina
Zdroj:	HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2020 May; Vol. 22 (5), pp. 735-743. Date of Electronic Publication: 2019 Oct 07.
DOI:	10.1016/j.hpb.2019.09.013
Abstrakt:	Background: Racial disparities are known to negatively impact survival in patients with pancreatic adenocarcinoma. However, data regarding the Hispanic ethnicity are scarce in the pancreatic cancer literature. Therefore, the aim of this study is to analyze whether race and ethnicity are independent predictors of survival in patients with pancreatic adenocarcinoma in Florida. Methods: A retrospective study was performed utilizing all patients diagnosed with pancreatic adenocarcinoma between 1983 and 2013 in the Florida Cancer Data System (FCDS). Statistical analysis was performed using Cox proportional hazard regression models, and Kaplan-Meier survival analysis. Results: Of 36,756 patients identified with pancreatic adenocarcinoma in the FCDS, 9.1% were Hispanic and 91% were non-Hispanic. Ethnicity was associated with improved survival among Hispanics compared to non-Hispanics (HR 0.86, 95% CI 0.82-0.90, both p = 0.001). Furthermore, 90% of patients were White, and 9% were Black. Compared to Whites, Blacks had a significantly decreased survival (HR 1.07, 95% CI 1.03-1.13, p = 0.003). Conclusion: In Florida patients with pancreatic adenocarcinoma, Hispanic ethnicity is associated with improved survival compared to Non-Hispanics. Additionally, Blacks present at an earlier age and later stage of diagnosis with worse survival compared to Whites and Others. (Copyright © 2019 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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