A Comprehensive Prospective Study of the Costs Associated With Evaluation of ß-Lactam Allergy.

Autor:	Sobrino-García M; Allergy Service, University Hospital of Salamanca, Salamanca, Spain., Muñoz-Bellido FJ; Allergy Service, University Hospital of Salamanca, Salamanca, Spain.; Institute for Biomedical Research of Salamanca, IBSAL, Salamanca, Spain.; Department of Biomedical and Diagnostic Sciences, Faculty of Medicine, University of Salamanca, Salamanca, Spain., Moreno E; Allergy Service, University Hospital of Salamanca, Salamanca, Spain.; Institute for Biomedical Research of Salamanca, IBSAL, Salamanca, Spain.; Department of Biomedical and Diagnostic Sciences, Faculty of Medicine, University of Salamanca, Salamanca, Spain.; Asthma, Allergic and Adverse Reactions (ARADyAL) Network for Cooperative Research in Health of Instituto de Salud Carlos III, Salamanca University Hospital, Salamanca, Spain., Macías E; Allergy Service, University Hospital of Salamanca, Salamanca, Spain.; Institute for Biomedical Research of Salamanca, IBSAL, Salamanca, Spain.; Department of Biomedical and Diagnostic Sciences, Faculty of Medicine, University of Salamanca, Salamanca, Spain., Gracia-Bara MT; Allergy Service, University Hospital of Salamanca, Salamanca, Spain.; Institute for Biomedical Research of Salamanca, IBSAL, Salamanca, Spain., Laffond E; Allergy Service, University Hospital of Salamanca, Salamanca, Spain.; Institute for Biomedical Research of Salamanca, IBSAL, Salamanca, Spain.; Department of Biomedical and Diagnostic Sciences, Faculty of Medicine, University of Salamanca, Salamanca, Spain., Lázaro-Sastre M; Allergy Service, University Hospital of Salamanca, Salamanca, Spain., Martín-García C; Allergy Service, University Hospital of Salamanca, Salamanca, Spain., de Arriba-Méndez S; Allergy Service, University Hospital of Salamanca, Salamanca, Spain.; Institute for Biomedical Research of Salamanca, IBSAL, Salamanca, Spain.; Department of Biomedical and Diagnostic Sciences, Faculty of Medicine, University of Salamanca, Salamanca, Spain., Campanón-Toro MV; Allergy Service, University Hospital of Salamanca, Salamanca, Spain., Gallardo-Higueras A; Allergy Service, University Hospital of Salamanca, Salamanca, Spain., Dávila I; Allergy Service, University Hospital of Salamanca, Salamanca, Spain.; Institute for Biomedical Research of Salamanca, IBSAL, Salamanca, Spain.; Department of Biomedical and Diagnostic Sciences, Faculty of Medicine, University of Salamanca, Salamanca, Spain.; Asthma, Allergic and Adverse Reactions (ARADyAL) Network for Cooperative Research in Health of Instituto de Salud Carlos III, Salamanca University Hospital, Salamanca, Spain.
Jazyk:	angličtina
Zdroj:	Journal of investigational allergology & clinical immunology [J Investig Allergol Clin Immunol] 2021 Feb 17; Vol. 31 (1), pp. 52-57. Date of Electronic Publication: 2019 Oct 10.
DOI:	10.18176/jiaci.0457
Abstrakt:	Background and Objective: Being labeled as allergic to penicillin (unverified ß-lactam allergy) can result in patients receiving broader-spectrum antibiotics than necessary that may be more toxic, less effective, and/or more expensive than alternative options. Objective: We aimed to evaluate the real costs of evaluating ß-lactam allergy. Methods: We performed a prospective real-life observational study designed to evaluate all adult patients who consulted for suspected ß-lactam allergy over a 1-year period. Direct and indirect costs were systematically recorded. Direct health costs were calculated based on the number of visits and all additional and diagnostic tests performed, direct nonhealth costs based on the number of visits and the distance from their homes to the Allergy Department, and indirect costs based on absenteeism. Results: A total of 296 patients with suspected allergy to ß-lactams were evaluated in our outpatient clinic from June 1, 2017 to May 31, 2018. Total direct health care costs were €28 176.70, with a mean (SD) cost of €95.19 (37.20). Direct nonhealth costs reached €6551.73, that is, €22.13 (40.44) per patient. Indirect health costs reached €20 769.20, with a mean of €70.17 (127.40). In summary, the total cost was €55 497.63, that is, a cost per patient of €187.49 (148.14). Conclusions: When all possible costs are taken into account, the evaluation of ß-lactam allergy is not expensive and can reduce future expense arising from unnecessary use of more expensive and less effective antibiotics.
Databáze:	MEDLINE
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