| Autor: |
Tolan HEM; Photochemistry Department, National Research Centre, Dokki, Giza, Egypt., El-Sayed WA; Photochemistry Department, National Research Centre, Dokki, Giza, Egypt.; Chemistry Department, Faculty of Science, Qassim University, Kingdom of Saudi Arabia., Tawfek N; Photochemistry Department, National Research Centre, Dokki, Giza, Egypt., Abdel-Megeid FME; Photochemistry Department, National Research Centre, Dokki, Giza, Egypt., Kutkat OM; Environmental Research Division, National Research Center, Dokki, Cairo, Egypt. |
| Abstrakt: |
New 1,2,3-triazole glycosides and 1,2,4-thioglycosides incorporating a substituted pyrimidinedione ring system were synthesized via click dipolar cycloaddition and heterocyclization of hydrazine-1-carbodithioate derivatives, respectively. The sugar hydrazine derivatives linked aminodimethyluracil were also prepared. In addition, the oxadiazoline substituted with acyclic sugar moieties linked to the pyrimidinedione as acyclic nucleoside analogs were synthesized. The antiviral activity of the synthesized compounds against avian influenza H5N1 virus was investigated and compounds 18 , 13 and 19 showed good activities against the virus strains. |
