| Autor: |
Dubinin MV; Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, Russia, 424001. dubinin1989@gmail.com., Tenkov KS; Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, Russia, 424001., Svinin AO; Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, Russia, 424001., Samartsev VN; Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, Russia, 424001., Belosludtsev KN; Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, Russia, 424001.; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow, Russia, 142290. |
| Abstrakt: |
The paper examines the effects of the antimicrobial agent triclosan on the functioning of the liver mitochondria of marsh frog (Pelophylax ridibundus (Pallas, 1771)). It was established that triclosan inhibits DNP-stimulated respiration of mitochondria and decreases respiratory control ratio. In addition, triclosan causes the collapse of the mitochondrial membrane potential on both types of substrates. Such an action of triclosan can be mediated by both a protonophore effect and suppression of the activity of complex II and combined activity of complexes II + III (and, to a lesser degree, the combined activity of complexes I + III) of the mitochondrial respiratory chain. It is shown that high concentrations of triclosan enhance the production of hydrogen peroxide during the oxidation of substrates of the complex I by mitochondria, and decrease it in the case of succinate oxidation. It is found that triclosan is able to induce nonspecific permeability of the liver mitochondria of these amphibians, as well as the plasma membrane of erythrocytes. The possible mechanisms of triclosan effect on marsh frog liver mitochondria and red blood cells are discussed. |
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