Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development.

Autor:	Tenney AP; Center for Motor Neuron Biology and Disease (MNC), Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA. Electronic address: alantenney@alumni.harvard.edu., Livet J; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France., Belton T; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA., Prochazkova M; Functional Genomics Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA., Pearson EM; Center for Motor Neuron Biology and Disease (MNC), Columbia University, New York, NY 10032, USA; Department of Neuroscience, Columbia University, New York, NY 10032, USA., Whitman MC; Department of Ophthalmology, Boston Children's Hospital/Harvard Medical School, Boston, MA 02115, USA., Kulkarni AB; Functional Genomics Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA., Engle EC; Department of Neurology, Boston Children's Hospital/Harvard Medical School, Boston, MA 02115, USA; Department of Ophthalmology, Boston Children's Hospital/Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Henderson CE; Center for Motor Neuron Biology and Disease (MNC), Columbia University, New York, NY 10032, USA; Columbia Stem Cell Initiative (CSCI), Columbia University, New York, NY 10032, USA; Columbia Translational Neuroscience Initiative (CTNI), Columbia University, New York, NY 10032, USA; Department of Rehabilitation and Regenerative Medicine, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University, New York, NY 10032, USA; Department of Neuroscience, Columbia University, New York, NY 10032, USA.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2019 Oct 08; Vol. 29 (2), pp. 437-452.e4.
DOI:	10.1016/j.celrep.2019.08.078
Abstrakt:	The somatotopic motor-neuron projections onto their cognate target muscles are essential for coordinated movement, but how that occurs for facial motor circuits, which have critical roles in respiratory and interactive behaviors, is poorly understood. We report extensive molecular heterogeneity in developing facial motor neurons in the mouse and identify markers of subnuclei and the motor pools innervating specific facial muscles. Facial subnuclei differentiate during migration to the ventral hindbrain, where neurons with progressively later birth dates-and evolutionarily more recent functions-settle in more-lateral positions. One subpopulation marker, ETV1, determines both positional and target muscle identity for neurons of the dorsolateral (DL) subnucleus. In Etv1 mutants, many markers of DL differentiation are lost, and individual motor pools project indifferently to their own and neighboring muscle targets. The resulting aberrant activation patterns are reminiscent of the facial synkinesis observed in humans after facial nerve injury. (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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