A Single Thermoresponsive Diblock Copolymer Can Form Spheres, Worms or Vesicles in Aqueous Solution.

Autor: Ratcliffe LPD; Department of Chemistry, Dainton Building, University of Sheffield, Brook Hill, South Yorkshire, S3 7HF, UK.; Present address: Unilever Research & Development, Colworth Laboratory, Colworth House, Sharnbrook, Bedford, MK44 1LQ, UK., Derry MJ; Department of Chemistry, Dainton Building, University of Sheffield, Brook Hill, South Yorkshire, S3 7HF, UK., Ianiro A; Laboratory of Physical Chemistry, Department of Chemical Engineering & Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600, MB, Eindhoven, The Netherlands., Tuinier R; Laboratory of Physical Chemistry, Department of Chemical Engineering & Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600, MB, Eindhoven, The Netherlands., Armes SP; Department of Chemistry, Dainton Building, University of Sheffield, Brook Hill, South Yorkshire, S3 7HF, UK.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Dec 19; Vol. 58 (52), pp. 18964-18970. Date of Electronic Publication: 2019 Nov 06.
DOI: 10.1002/anie.201909124
Abstrakt: It is well-known that the self-assembly of AB diblock copolymers in solution can produce various morphologies depending on the relative volume fraction of each block. Recently, polymerization-induced self-assembly (PISA) has become widely recognized as a powerful platform technology for the rational design and efficient synthesis of a wide range of block copolymer nano-objects. In this study, PISA is used to prepare a new thermoresponsive poly(N-(2-hydroxypropyl) methacrylamide)-poly(2-hydroxypropyl methacrylate) [PHPMAC-PHPMA] diblock copolymer. Remarkably, TEM, rheology and SAXS studies indicate that a single copolymer composition can form well-defined spheres (4 °C), worms (22 °C) or vesicles (50 °C) in aqueous solution. Given that the two monomer repeat units have almost identical chemical structures, this system is particularly well-suited to theoretical analysis. Self-consistent mean field theory suggests this rich self-assembly behavior is the result of the greater degree of hydration of the PHPMA block at lower temperature, which is in agreement with variable temperature 1 H NMR studies.
(© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)
Databáze: MEDLINE
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