Models of the Gut for Analyzing the Impact of Food and Drugs.

Autor: Fois CAM; School of Chemical and Biomolecular Engineering, Centre for Advanced Food Enginomics, University of Sydney, Sydney, NSW, 2006, Australia., Le TYL; School of Chemical and Biomolecular Engineering, Centre for Advanced Food Enginomics, University of Sydney, Sydney, NSW, 2006, Australia., Schindeler A; School of Chemical and Biomolecular Engineering, Centre for Advanced Food Enginomics, University of Sydney, Sydney, NSW, 2006, Australia., Naficy S; School of Chemical and Biomolecular Engineering, Centre for Advanced Food Enginomics, University of Sydney, Sydney, NSW, 2006, Australia., McClure DD; School of Chemical and Biomolecular Engineering, Centre for Advanced Food Enginomics, University of Sydney, Sydney, NSW, 2006, Australia., Read MN; School of Chemical and Biomolecular Engineering, Centre for Advanced Food Enginomics, University of Sydney, Sydney, NSW, 2006, Australia., Valtchev P; School of Chemical and Biomolecular Engineering, Centre for Advanced Food Enginomics, University of Sydney, Sydney, NSW, 2006, Australia., Khademhosseini A; Department of Chemical and Biomolecular Engineering, Department of Bioengineering, Department of Radiology, California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095, USA., Dehghani F; School of Chemical and Biomolecular Engineering, Centre for Advanced Food Enginomics, University of Sydney, Sydney, NSW, 2006, Australia.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2019 Nov; Vol. 8 (21), pp. e1900968. Date of Electronic Publication: 2019 Oct 08.
DOI: 10.1002/adhm.201900968
Abstrakt: Models of the human gastrointestinal tract (GIT) can be powerful tools for examining the biological interactions of food products and pharmaceuticals. This can be done under normal healthy conditions or using models of disease-many of which have no curative therapy. This report outlines the field of gastrointestinal modeling, with a particular focus on the intestine. Traditional in vivo animal models are compared to a range of in vitro models. In vitro systems are elaborated over time, recently culminating with microfluidic intestines-on-chips (IsOC) and 3D bioengineered models. Macroscale models are also reviewed for their important contribution in the microbiota studies. Lastly, it is discussed how in silico approaches may have utility in predicting and interpreting experimental data. The various advantages and limitations of the different systems are contrasted. It is posited that only through complementary use of these models will salient research questions be able to be addressed.
(© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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