Maternal obesity accelerates rat offspring metabolic ageing in a sex-dependent manner.
Autor: | Rodríguez-González GL; Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Reyes-Castro LA; Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Bautista CJ; Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Beltrán AA; Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Ibáñez CA; Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Vega CC; Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Lomas-Soria C; Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; CONACyT-Cátedras, Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Castro-Rodríguez DC; Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; CONACyT-Cátedras, Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Elías-López AL; CONACyT-Cátedras, Instituto Nacional de Salud Pública, Mexico City, Mexico., Nathanielsz PW; Wyoming Center for Pregnancy and Life Course Health Research, Department of Animal Science, University Wyoming, Laramie, WY, USA., Zambrano E; Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. |
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Jazyk: | angličtina |
Zdroj: | The Journal of physiology [J Physiol] 2019 Dec; Vol. 597 (23), pp. 5549-5563. Date of Electronic Publication: 2019 Nov 11. |
DOI: | 10.1113/JP278232 |
Abstrakt: | Key Points: Maternal obesity predisposes to metabolic dysfunction in male and female offspring Maternal high-fat diet consumption prior to and throughout pregnancy and lactation accelerates offspring metabolic ageing in a sex-dependent manner This study provides evidence for programming-ageing interactions ABSTRACT: Human epidemiological studies show that maternal obesity (MO) shortens offspring life and health span. Life course cellular mechanisms involved in this developmental programming-ageing interaction are poorly understood. In a well-established rat MO model, female Wistar rats ate chow (controls (C)) or high energy, obesogenic diet to induce MO from weaning through pregnancy and lactation. Females were bred at postnatal day (PND) 120. Offspring (F Conclusions: exposure to the developmental challenge of MO accelerates progeny ageing metabolic and endocrine profiles in a sex specific manner, providing evidence for programming-ageing interactions. (© 2019 The Authors. The Journal of Physiology © 2019 The Physiological Society.) |
Databáze: | MEDLINE |
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