Smart textiles in wound care: functionalization of cotton/PET blends with antimicrobial nanocapsules.

Autor:	Quartinello F; University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Environmental Biotechnology, Department for Agrobiotechnology (IFA-Tulln), Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria. alessandro.pellis@boku.ac.at alessandro.pellis@gmail.com., Tallian C; University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Environmental Biotechnology, Department for Agrobiotechnology (IFA-Tulln), Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria. alessandro.pellis@boku.ac.at alessandro.pellis@gmail.com., Auer J; University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Environmental Biotechnology, Department for Agrobiotechnology (IFA-Tulln), Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria. alessandro.pellis@boku.ac.at alessandro.pellis@gmail.com., Schön H; University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Environmental Biotechnology, Department for Agrobiotechnology (IFA-Tulln), Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria. alessandro.pellis@boku.ac.at alessandro.pellis@gmail.com., Vielnascher R; University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Environmental Biotechnology, Department for Agrobiotechnology (IFA-Tulln), Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria. alessandro.pellis@boku.ac.at alessandro.pellis@gmail.com and Austrian Centre of Industrial Biotechnology, Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria., Weinberger S; University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Environmental Biotechnology, Department for Agrobiotechnology (IFA-Tulln), Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria. alessandro.pellis@boku.ac.at alessandro.pellis@gmail.com., Wieland K; Institute of Chemical Technologies and Analytics, Division Environmental Process, Analytics and Sensors, TU Wien, Getreidemarkt 9/164 AC, 1060 Vienna, Austria., Weihs AM; Department of Biochemical Engineering, University of Applied Sciences Technikum Wien, 1200 Vienna, Austria and Austrian Cluster for Tissue Regeneration, Vienna, Austria., Herrero-Rollett A; University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Environmental Biotechnology, Department for Agrobiotechnology (IFA-Tulln), Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria. alessandro.pellis@boku.ac.at alessandro.pellis@gmail.com., Lendl B; Institute of Chemical Technologies and Analytics, Division Environmental Process, Analytics and Sensors, TU Wien, Getreidemarkt 9/164 AC, 1060 Vienna, Austria., Teuschl AH; Department of Biochemical Engineering, University of Applied Sciences Technikum Wien, 1200 Vienna, Austria and Austrian Cluster for Tissue Regeneration, Vienna, Austria., Pellis A; University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Environmental Biotechnology, Department for Agrobiotechnology (IFA-Tulln), Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria. alessandro.pellis@boku.ac.at alessandro.pellis@gmail.com and Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., Guebitz GM; University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Environmental Biotechnology, Department for Agrobiotechnology (IFA-Tulln), Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria. alessandro.pellis@boku.ac.at alessandro.pellis@gmail.com and Austrian Centre of Industrial Biotechnology, Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria.
Jazyk:	angličtina
Zdroj:	Journal of materials chemistry. B [J Mater Chem B] 2019 Nov 14; Vol. 7 (42), pp. 6592-6603. Date of Electronic Publication: 2019 Oct 07.
DOI:	10.1039/c9tb01474h
Abstrakt:	Management of infected wounds is one of the most costly procedures in the health care sector. Burn wounds are of significant importance due to the high infection risk that can possibly lead to severe consequences such as sepsis. Because antibiotic wound treatments have caused increasing antibiotic resistance in bacteria, there is currently a strong need for alternative strategies. Therefore, we developed new antimicrobial wound dressings consisting of pH-responsive human serum albumin/silk fibroin nanocapsules immobilized onto cotton/polyethylene terephthalate (PET) blends loaded with eugenol, which is an antimicrobial phenylpropanoid. Ultrasound-assisted production of eugenol-loaded nanocapsules resulted in particle sizes (hydrodynamic radii) between 319.73 ± 17.50 and 574.00 ± 92.76 nm and zeta potentials ranging from -10.39 ± 1.99 mV to -12.11 ± 0.59 mV. Because recent discoveries have indicated that the sweat glands contribute to wound reepithelialisation, release studies of eugenol were conducted in different artificial sweat formulas that varied in pH. Formulations containing 10% silk fibroin with lower degradation degree exhibited the highest release of 41% at pH 6.0. After immobilization, the functionalized cotton/PET blends were able to inhibit 81% of Staphylococcus aureus and 33% of Escherichia coli growth. Particle uniformity, silk fibroin concentration, and high surface-area-to-volume ratio of the produced nanocapsules were identified as the contributing factors leading to high antimicrobial activities against both strains. Therefore, the production of antimicrobial textiles using nanocapsules loaded with an active natural compound that will not contribute to antibiotic resistance is seen as a potential future alternative to commercially available antiseptic wound dressings.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu