Testing of novel spectral device sensor in swine model of airway obstruction.

Autor: Blackburn MB; Tactical and En Route Care Department, U.S. Army Institute of Surgical Research, JBSA, Fort Sam Houston, Texas., Nawn CD; Tactical and En Route Care Department, U.S. Army Institute of Surgical Research, JBSA, Fort Sam Houston, Texas.; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas., Ryan KL; Tactical and En Route Care Department, U.S. Army Institute of Surgical Research, JBSA, Fort Sam Houston, Texas.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2019 Oct; Vol. 7 (19), pp. e14246.
DOI: 10.14814/phy2.14246
Abstrakt: Loss of a patent airway is a significant cause of prehospital death. Endotracheal intubation is the gold standard of care but has a high rate of failure and complications, making development of new devices vital. We previously showed that tracheal tissue has a unique spectral profile which could be utilized to confirm correct airway device placement. Therefore, the goals of this study were twofold: 1- to develop an airway obstruction model and 2- use that model to assess how airway compromise affects tissue reflectance. Female swine were anesthetized, intubated, and instrumented. Pigs were allowed to breathe spontaneously and underwent either slow- or rapid-onset obstruction until a real-time pulse oximeter reading of ≤50%. At baseline, 25%, 50%, 75%, and 100% obstruction, a fiber-optic reflection probe was inserted into the trachea and esophagus to capture reflectance spectra. Both slow- and rapid-onset obstruction significantly decreased arterial oxygen concentration (sO 2 ) and increased partial pressure of CO 2 (pCO 2 ). The presence of the tracheal-defining spectral profile was confirmed and remained consistent despite changes in sO 2 and pCO 2 . This study validated a model of slow- and rapid-airway obstruction that results in significant hypoxia and hypercapnia. This is valuable for future testing of airway device components that may improve airway management. Additionally, our data support the ability of spectral reflectance to differentiate between tracheal and esophageal tissues in the presence of a clinical condition that decreases oxygen saturation.
(© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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