Two new 23S,26R-hydroxylated spirostanoid saponins from the fruits of Solanum indicum var. recurvatum.

Autor: Kaunda JS; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China., Zhang YJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: zhangyj@mail.kib.ac.cn.
Jazyk: angličtina
Zdroj: Steroids [Steroids] 2020 Jan; Vol. 153, pp. 108506. Date of Electronic Publication: 2019 Oct 03.
DOI: 10.1016/j.steroids.2019.108506
Abstrakt: Solanum indicum var. recurvatum, distributed mainly in Hekou, Simao and Menghai areas of Yunnan province, China, is characterized by stellate pubescent leaves with irregular lengths and oblong, short, and downwardly curved anthers. The original species, S. indicum, has been used as an anti-inflammatory, wound-healing agent, an analgesic, and for the treatment of rhinitis, cough, and breast cancer in Chinese folk medicine. The variety was chemically studied for the first time, leading to the isolation of two new rare 23S,26R-hydroxylated spirostanoid saponins, together with five known steroidal components, two of which the rare natural ketosteroids 6-hydroxyandrosta-1,4-diene-3,17-dione and rostadienedione have been isolated from the genus Solanum for the first time. Elucidation of the structures was accomplished by extensive 1D and 2D NMR, UV, and HRESIMS spectroscopic methods.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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