Warfarin-induced vitamin K deficiency affects spermatogenesis in Sprague-Dawley rats.

Autor: Sanyaolu AO; Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria., Oremosu AA; Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria., Osinubi AA; Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria., Vermeer C; R&D Group VitaK, Maastricht University, Maastricht, The Netherlands., Daramola AO; Department of Anatomic & Molecular Pathology, College of Medicine, University of Lagos, Lagos, Nigeria.
Jazyk: angličtina
Zdroj: Andrologia [Andrologia] 2019 Nov; Vol. 51 (10), pp. e13416. Date of Electronic Publication: 2019 Oct 01.
DOI: 10.1111/and.13416
Abstrakt: Vitamin K is present in the testes though its actual function in male reproduction is poorly understood. This study investigated the harmful effect of extrahepatic vitamin K insufficiency on the testicular structure. Sprague-Dawley rats were fed with a diet containing warfarin for 2, 4 and 8 weeks; control animals received a standard diet without warfarin. It was found that extrahepatic vitamin K deficiency that is induced by warfarin results in histopathological features that range from delayed spermiation, presence of multinucleated giant cells in the seminiferous tubules, germ cells degeneration, asthenozoospermia, oligozoospermia and increase in the percentage of abnormal sperm morphology when compared to the controls. Data obtained from the two groups were analysed using the Student t test. It is concluded that warfarin-induced vitamin K deficiency has a negative impact on spermatogenesis.
(© 2019 Blackwell Verlag GmbH.)
Databáze: MEDLINE
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