Discovery of Metabolic Biomarkers Predicting Radiation Therapy Late Effects in Prostate Cancer Patients.

Autor:	Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA., Grindrod S; Shuttle Pharmaceuticals Inc, Rockville, MD, USA., Zhong X; Department of Biostatistics and Biomathematics, Georgetown University Medical Center, Washington, DC, USA., Jain S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Menon SS; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Mehta KY; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Suy S; Department of Radiation Medicine, Medstar-Georgetown University Hospital, Washington, DC, USA., Collins S; Department of Radiation Medicine, Medstar-Georgetown University Hospital, Washington, DC, USA., Wang Y; Department of Biostatistics and Biomathematics, Georgetown University Medical Center, Washington, DC, USA., Timofeeva O; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Bandi G; Department of Urology, Medstar-Georgetown University Hospital, Washington, DC, USA., Pahira J; Department of Urology, Medstar-Georgetown University Hospital, Washington, DC, USA., Kowalczyk K; Department of Urology, Medstar-Georgetown University Hospital, Washington, DC, USA., Lynch J; Department of Urology, Medstar-Georgetown University Hospital, Washington, DC, USA., Dritschilo A; Shuttle Pharmaceuticals Inc, Rockville, MD, USA. dritscha@georgetown.edu.; Department of Radiation Medicine, Medstar-Georgetown University Hospital, Washington, DC, USA. dritscha@georgetown.edu.
Jazyk:	angličtina
Zdroj:	Advances in experimental medicine and biology [Adv Exp Med Biol] 2019; Vol. 1164, pp. 141-150.
DOI:	10.1007/978-3-030-22254-3_11
Abstrakt:	Patients presenting with prostate cancers undergo clinical staging evaluations to determine the extent of disease to guide therapeutic recommendations. Management options may include watchful waiting, surgery, or radiation therapy. Thus, initial risk stratification of prostate cancer patients is important for achieving optimal therapeutic results or cancer cure and preservation of quality of life. Predictive biomarkers for risks of complications or late effects of treatment are needed to inform clinical decisions for treatment selection. Here, we analyzed pre-treatment plasma metabolites in a cohort of prostate cancer patients (N = 99) treated with Stereotactic Body Radiation Therapy (SBRT) at Medstar-Georgetown University Hospital in a longitudinal, quality-of-life study to determine if individuals experiencing radiation toxicities can be identified by a molecular profile in plasma prior to treatment. We used a multiple reaction mass spectrometry-based molecular phenotyping of clinically annotated plasma samples in a retrospective outcome analysis to identify candidate biomarker panels correlating with adverse clinical outcomes following radiation therapy. We describe the discovery of candidate biomarkers, based on small molecule metabolite panels, showing high correlations (AUCs ≥ 95%) with radiation toxicities, suitable for validation studies in an expanded cohort of patients.
Databáze:	MEDLINE
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