Increased choroidal thickness in primary angle closure measured by swept-source optical coherence tomography in Caucasian population.

Autor: Nguyen DT; Ophthalmology Department, Necker-Enfants Malades Hospital, Paris, France., Giocanti-Aurégan A; Ophthalmology Department, Avicenne Hospital, 125 rue de Stalingrad, 93000, Bobigny, France. Audrey.giocanti@aphp.fr., Benhatchi N; Ophthalmology Department, Glaucoma Institute, Saint Joseph Hospital, Paris, France., Greliche N; James Cook University, Singapore, Singapore., Beaussier H; Clinical Research Center, Saint Joseph Hospital, Paris, France., Sustronck P; Ophthalmology Department, Intercommunal Hospital of Creteil, Créteil, France., Hammoud S; Ophthalmology Department, Glaucoma Institute, Saint Joseph Hospital, Paris, France., Jeanteur MN; Ophthalmology Department, Glaucoma Institute, Saint Joseph Hospital, Paris, France., Kretz G; Ophthalmology Department, Glaucoma Institute, Saint Joseph Hospital, Paris, France., Abitbol O; Ophthalmology Department, Glaucoma Institute, Saint Joseph Hospital, Paris, France., Lachkar Y; Ophthalmology Department, Glaucoma Institute, Saint Joseph Hospital, Paris, France.
Jazyk: angličtina
Zdroj: International ophthalmology [Int Ophthalmol] 2020 Jan; Vol. 40 (1), pp. 195-203. Date of Electronic Publication: 2019 Oct 01.
DOI: 10.1007/s10792-019-01171-z
Abstrakt: Purpose: A role of the choroid has been suggested in the pathophysiology of angle closure. We assessed the choroidal thickness (CT) in Caucasian patients with primary angle closure (PAC) and in a subgroup of patients with plateau iris using swept-source optical coherence tomography (SS-OCT) compared to normal eyes.
Methods: This prospective cohort study in a hospital-based population in a tertiary center compared consecutive patients with PAC to healthy controls. A subgroup analysis of patients with plateau iris was also performed. Choroidal thickness was measured by SS-OCT in the subfoveal area (SFCT) and at 1- and 3-mm eccentricity superiorly, inferiorly, nasally and temporally from the fovea.
Results: Compared to the 25 eyes of 13 control patients [7 women, mean (SD) age, 56.6 (15.7) years], the 45 eyes of 25 patients with PAC [15 women, mean (SD) age, 55.7 (10.7) years] had a significantly increased SFCT. SFCT was 355.36 μm (SD 85.97) in PAC eyes versus 286.08 μm (SD 98.09) in control eyes (p = 0.009). The CT was also significantly increased compared to control eyes in other macular areas (p < 0.05), except at 3 mm temporal to the fovea. In the plateau iris subgroup, a not significant (except 3 mm nasal to the fovea) trend toward an increased CT was observed in all studied macular areas compared to control eyes.
Conclusion: In eyes of Caucasian patients with PAC, the CT is increased compared to controls. Increased CT could contribute to the pathophysiology of PAC with a possible choroidal expansion and dysfunction of choroidal ganglion cells.
Databáze: MEDLINE
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