Who is young at heart and when? Diastolic Doppler data from the mind your heart study.

Autor: Abuzaid A; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Cardiology, University of California San Francisco, San Francisco, CA, USA., Cohen BE; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA., Pursnani S; Division of Cardiology, Kaiser Permanente, Santa Clara, CA, USA., Lahsaeizadeh S; Division of Cardiology, Department of Medicine, California Pacific Medical Center, San Francisco, CA, USA., Ristow B; Division of Cardiology, Department of Medicine, California Pacific Medical Center, San Francisco, CA, USA., Shaw RE; Division of Cardiology, Department of Medicine, California Pacific Medical Center, San Francisco, CA, USA.; Division of Cardiology, Contra Costa Regional Medical Center, Contra Costa County, CA, USA., Rosenblatt A; Division of Cardiology, Department of Medicine, California Pacific Medical Center, San Francisco, CA, USA., Fang Q; Department of Medicine and Cardiovascular Research Center, University of California, San Francisco, CA, USA., Schiller NB; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Cardiology, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.; Department of Medicine and Cardiovascular Research Center, University of California, San Francisco, CA, USA.
Jazyk: angličtina
Zdroj: Echocardiography (Mount Kisco, N.Y.) [Echocardiography] 2019 Sep; Vol. 36 (9), pp. 1744-1746. Date of Electronic Publication: 2019 Oct 01.
DOI: 10.1111/echo.14468
Abstrakt: To further define the age-related distribution of diastolic function as defined by E/A ratio, in healthy male adults. The age-sensitive ratio of mitral inflow E-wave to A-wave (E/A) velocity is often considered in the evaluation of diastolic function. To appropriately direct a comprehensive evaluation of diastolic function, we sought to improve the characterization of the influence of age on E/A ratio. We analyzed echocardiographic data from the Mind Your heart Study, a cohort of outpatients recruited from two San Francisco Veterans centers to examine the effect of mental health on cardiovascular outcomes. Individuals with a history of heart disease or hypertension were excluded, leaving 313 veterans for analysis. We examined E/A by 5-year increments and performed linear and logistic regression analysis to predict trends in E/A and E dominance. Within the age ranges of population (54.9 ± 11.5), there is a steady gradual decline in absolute E/A ratio (beta coefficient/year- 0.018, P < .001) and the odds of E dominance similarly declines with age (odds ratio/year = 0.89, P < .001). Despite this decline, 90% of individuals below the age of 50 years maintain E dominance. Beyond age 50, 55% maintain E dominance, and beyond age 70, only 28% have E dominance. In this adequately healthy population, age-related progression of delayed relaxation appears to be a state of normality rather than diastolic dysfunction. Careful attention to specific cutoff points in age and E/A ratio could avoid misinterpretation or inappropriate management.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje