Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease.

Autor: Tarasova NV; Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Trubetskaya str. 8, bld. 2, Moscow 119991, Russia. compasstar@gmail.com., Vishnyakova PA; National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow 117997, Russia. vpa2002@mail.ru., Logashina YA; Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Trubetskaya str. 8, bld. 2, Moscow 119991, Russia. yulia.logashina@gmail.com.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street 16/10, Moscow 117997, Russia. yulia.logashina@gmail.com., Elchaninov AV; National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow 117997, Russia. elchandrey@yandex.ru.; Scientific Research Institute of Human Morphology, 3 Tsurupa Street, Moscow 117418, Russia. elchandrey@yandex.ru.; Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, Moscow 117198, Russia. elchandrey@yandex.ru.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2019 Sep 28; Vol. 20 (19). Date of Electronic Publication: 2019 Sep 28.
DOI: 10.3390/ijms20194823
Abstrakt: Calcium ions (Ca 2+ ) influx to mitochondrial matrix is crucial for the life of a cell. Mitochondrial calcium uniporter (mtCU) is a protein complex which consists of the pore-forming subunit (MCU) and several regulatory subunits. MtCU is the main contributor to inward Ca 2+ currents through the inner mitochondrial membrane. Extensive investigations of mtCU involvement into normal and pathological molecular pathways started from the moment of discovery of its molecular components. A crucial role of mtCU in the control of these pathways is now recognized in both health and disease. In particular, impairments of mtCU function have been demonstrated for cardiovascular and skeletal muscle-associated pathologies. This review summarizes the current state of knowledge on mtCU structure, regulation, and function in different types of muscle tissues in health and disease.
Databáze: MEDLINE
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