Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study.

Autor: Smilnak GJ; Department of Ophthalmology, Duke University Medical Center, Durham, NC, United States of America., Deans JR; Department of Ophthalmology, Duke University Medical Center, Durham, NC, United States of America., Doraiswamy PM; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States of America., Stinnett S; Department of Ophthalmology, Duke University Medical Center, Durham, NC, United States of America., Whitson HE; Department of Internal Medicine, Division of Geriatrics, Duke University Medical Center, Durham, NC, United States of America., Lad EM; Department of Ophthalmology, Duke University Medical Center, Durham, NC, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2019 Sep 30; Vol. 14 (9), pp. e0223199. Date of Electronic Publication: 2019 Sep 30 (Print Publication: 2019).
DOI: 10.1371/journal.pone.0223199
Abstrakt: Introduction: Previous studies evaluating the association between clinically diagnosed Alzheimer's disease (AD) and age-related macular degeneration (AMD) have generated conflicting results. This study is the first to assess whether AMD prevalence is higher in AD patients than non-AD controls by using histopathology to definitively diagnose AD.
Methods: This was a retrospective case-control study utilizing diagnostic information extracted from autopsy reports of patients age 75 and above, including 115 with a neuropathological diagnosis of AD and 57 age-matched normal controls.
Results: The rate of AMD was not significantly higher in AD cases (53.0%) than in controls (59.6%) (z = 0.820, p = 0.794). AMD severity as determined by Sarks score was similar between AD patients and controls (χ2 = 2.96, p = 0.706). There was also no significant association between Braak stage of AD severity and AMD (χ2 = 4.55, p = 0.602).
Discussion: No significant effect of AD diagnosis or pathologic severity on AMD comorbidity was found, suggesting that any shared mechanisms between AMD and AD may be nondeterministic.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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