Duration of Pivalate-conjugated Antibiotics and Blood Glucose Levels Among Pediatric Inpatients: Causal Mediation Analyses and Systematic Review.
| Autor: | Sugitate R; From the Department of Pediatrics, Maebashi Red Cross Hospital, Gunma, Japan., Okubo Y; Department of Epidemiology, UCLA Fielding School of Public Health, California.; Department of Social Medicine, National Center for Child Health and Development, Japan., Matsui A; From the Department of Pediatrics, Maebashi Red Cross Hospital, Gunma, Japan. |
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| Jazyk: | angličtina |
| Zdroj: | The Pediatric infectious disease journal [Pediatr Infect Dis J] 2019 Dec; Vol. 38 (12), pp. 1214-1218. |
| DOI: | 10.1097/INF.0000000000002460 |
| Abstrakt: | Background: Several cases of hypoglycemia potentially induced by pivalate-conjugated antibiotics have been reported. However, no observational studies have investigated the associations among children. Method: A retrospective cohort study was conducted on 814 consecutive inpatients < 15 years of age with lower respiratory infections. We investigated whether the duration of lower respiratory symptoms and antibiotic use on blood glucose levels and their mediating/moderating effects using multivariable linear regression models and causal mediation analyses. Additionally, we performed a systematic review of the literature that reported the potential associations between pivalate-conjugated antibiotics and hypoglycemia. Results: Multivariable linear regression models showed that the duration of respiratory symptoms and fever had independent relationships with the reduction in blood glucose levels, whereas duration of pivalate-conjugated antibiotic use did not. Causal mediation analyses found that the controlled direct effects of respiratory symptom duration contributed to the reduction in blood glucose levels, but the mediating/moderating effects through antibiotic use did not. A systematic review of the literature included 7 reports written in English and 14 reports written in Japanese. No reports were observational studies; therefore, we were unable to conduct a meta-analysis. Conclusions: Our study failed to demonstrate an association between duration of pivalate-conjugated antibiotic use and blood glucose levels. Further studies are required to illuminate the relationship. |
| Databáze: | MEDLINE |
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