Apparent therapy-resistant hypertension as risk factor for the development of type 2 diabetes mellitus.
| Autor: | Holtrop J; Department of Vascular Medicine Department of Cardiology Department of Vascular Surgery Department of Neurology and Neurosurgery Department of Diabetology, University Medical Centre Utrecht, Utrecht, The Netherlands., Spiering W, Nathoe HM, De Borst GJ, Kappelle LJ, De Valk HW, Visseren FLJ, Westerink J |
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| Jazyk: | angličtina |
| Zdroj: | Journal of hypertension [J Hypertens] 2020 Jan; Vol. 38 (1), pp. 45-51. |
| DOI: | 10.1097/HJH.0000000000002227 |
| Abstrakt: | Objective: To evaluate whether the relationship between hypertension and type 2 diabetes mellitus (T2DM) is different for patients with uncontrolled hypertension, controlled hypertension or patients with apparent therapy-resistant hypertension (aTRH), compared with patients without hypertension. Methods: Using Cox proportional hazard models we evaluated the risk of new-onset T2DM in 8756 patients, at high risk for vascular disease. Hypertensive patients were subdivided according to blood pressure (BP) and use of BP-lowering drugs. BP ≥ 140/90 mmHg was defined as uncontrolled BP. aTRH was defined as uncontrolled BP despite being treated with at least three BP-lowering drugs including a diuretic, or the use at least four BP-lowering drugs irrespective of BP levels. Further analysis evaluated the risk of new-onset T2DM for patients with uncontrolled hypertension and for patients with aTRH, compared with patients with controlled hypertension and without hypertension, respectively. Results: Forty-five percent had controlled hypertension, 20% had uncontrolled hypertension, 5.7% had aTRH, and 29% were nonhypertensive. During a follow-up of 7.0 (interquartile range: 0-14) years there were 705 new cases of T2DM. Patients with hypertension had a 1.48 (95% confidence interval 1.22-1.80) times higher risk of new-onset T2DM than nonhypertensive patients. There was no significant difference in risk among different hypertension groups. Conclusion: Patients at high risk for cardiovascular disease with hypertension have a 1.48 times higher risk of new-onset T2DM than nonhypertensive counterparts. The risk did not differ between patients with controlled hypertension, uncontrolled hypertension, or aTRH. |
| Databáze: | MEDLINE |
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