Disease Severity and Quality of Life Outcome Measurements in Patients With Keloids: A Systematic Review.
| Autor: | Lyons AB; Department of Dermatology, Henry Ford Hospital Systems, Detroit, Michigan., Peacock A; Department of Internal Medicine, St. Mary Mercy Hospital, Livonia, Michigan., Braunberger TL; Department of Dermatology, Henry Ford Hospital Systems, Detroit, Michigan., Viola KV; Department of Dermatology, Henry Ford Hospital Systems, Detroit, Michigan., Ozog DM; Department of Dermatology, Henry Ford Hospital Systems, Detroit, Michigan. |
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| Jazyk: | angličtina |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2019 Dec; Vol. 45 (12), pp. 1477-1483. |
| DOI: | 10.1097/DSS.0000000000002172 |
| Abstrakt: | Background: Keloids have been assessed by numerous methods and severity indices resulting in a lack of standardization across published research. Objective: This study aims to evaluate published keloid randomized controlled trials (RCTs) and identify the need for a gold standard of assessment. Methods and Materials: PubMed, MEDLINE, and Embase were searched for human RCTs on keloid treatment during a 10-year period. Eligible studies were English language RCTs reporting disease severity outcome measures after keloid treatments. Results: A total of 40 disease outcome measures were used in 41 included RCTs. Twenty-four (59%) of the included studies used more than one disease severity scale. The most frequently used outcome measures were the Vancouver Scar Scale (34%) (n = 14), followed by serial photography (24%) (n = 10). These were followed by adverse events and complications (20%) (n = 8), Visual Analogue Scale (12%) (n = 5), keloid dimensions (12%) (n = 5), and Patient and Observer Scar Assessment Scale (10%) (n = 4). Only one study reported quality of life outcomes. Conclusion: There is wide variation in keloid outcome measures in the published literature. A standardized method of assessment should be implemented to reduce the disparities between studies and to better be able to compare the numerous treatment modalities. |
| Databáze: | MEDLINE |
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