| Autor: |
Golovko VA; Institute of Physiology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, FRC Komi SC UB RAS, Syktyvkar, Komi Republic, Russian Federation. golovko@physiol.komisc.ru., Kozlovskaya AV; Medical Institute of Federal State Syktyvkar University, Syktyvkar, Komi Republic, Russian Federation., Gonotkov MA; Institute of Physiology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, FRC Komi SC UB RAS, Syktyvkar, Komi Republic, Russian Federation. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society [J Physiol Pharmacol] 2019 Jun; Vol. 70 (3). Date of Electronic Publication: 2019 Sep 27. |
| DOI: |
10.26402/jpp.2019.3.12 |
| Abstrakt: |
We hypothesized that the repolarization phase of action potentials (APs) in mammals with large body mass and high cardiac output could not be reliably controlled by only one of the delayed rectifier potassium I K current components. To test this hypothesis experimentally, we performed a comparative study of the response of AP phases to the rapid I Kr channels blocker E-4031 and slow I Ks blocker chromanol 293B in APs spontaneously generated in strips of sinoauricular (SA) tissue from mouse, guinea pig, and pig hearts. Application of a slow channels blocker chromanol 293B caused a decrease of Aps generation frequency in SA area strips from mouse, guinea-pig and pig by 5.3, 16, and 18% compared to the control. Treatment with the I Kr blocker E-4031 caused a significant reduction of APs generation frequency in the mouse, guinea pig, and pig SA strips by 24, 26, and 36%, respectively, compared to the control values. These results suggest that the rapid I Kr current is the key component responsible for AP generation in sinoauricular node cells of the pig heart. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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