RcsB-dependent effects on nar operon regulation during the aerobic growth of Salmonella Typhimurium.

Autor: Torrez Lamberti MF; Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, And Instituto de Química Biológica 'Dr. Bernabé Bloj', Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI, San Miguel de Tucumán, Argentina., Ballesteros MF; Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, And Instituto de Química Biológica 'Dr. Bernabé Bloj', Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI, San Miguel de Tucumán, Argentina., López FE; Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, And Instituto de Química Biológica 'Dr. Bernabé Bloj', Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI, San Miguel de Tucumán, Argentina; Universidad Nacional de Chilecito (UNdeC), 9 de Julio 22, F5360CKB, Chilecito, La Rioja, Argentina., Pescaretti MLM; Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, And Instituto de Química Biológica 'Dr. Bernabé Bloj', Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI, San Miguel de Tucumán, Argentina. Electronic address: merpescaretti@hotmail.com., Delgado MA; Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, And Instituto de Química Biológica 'Dr. Bernabé Bloj', Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI, San Miguel de Tucumán, Argentina. Electronic address: monicad@fbqf.unt.edu.ar.
Jazyk: angličtina
Zdroj: Biochimie [Biochimie] 2019 Dec; Vol. 167, pp. 152-161. Date of Electronic Publication: 2019 Sep 27.
DOI: 10.1016/j.biochi.2019.09.014
Abstrakt: The intracellular pathogen Salmonella is an important cause of human foodborne diseases worldwide. Salmonella takes advantage of the phosphorelay regulatory systems to survive in the hostile environment of the host's gastrointestinal tract. It has been reported that the nitrate reductase Z (NR-Z), encoded by the narUZYV operon, is required during Salmonella transition to anaerobic environments and is constitutively produced at low levels, but little is known about the regulatory mechanism involved in the operon gene expression. In this work, we found that the RcsCDB system is activated by high concentrations of specific sugars as a carbon source. In this activation state, the RcsCDB system participates in the negative control of narUZYWV expression. This control strategy occurs during exponential growth when the carbon source is high, allowing for normal aerobic respiration. The RcsCDB system's participation in aerobic respiration is necessary to ensure efficient metabolism and optimal energy consumption when the bacteria are growing exponentially.
(Copyright © 2019 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.)
Databáze: MEDLINE
Externí odkaz: