Cerebral Venous Sinus Thrombosis as a Rare Complication of Systemic Lupus Erythematosus: Subgroup Analysis of the VENOST Study.

Autor: Duman T; Department of Neurology, Mustafa Kemal University, School of Medicine, Hatay, Turkey. Electronic address: taskinduman@yahoo.com., Demirci S; Department of Neurology, Aspendos Anatolian Hospital, Antalya, Turkey., Uluduz D; Department of Neurology, Istanbul University, Cerrahpasa School of Medicine, İstanbul, Turkey., Kozak HH; Department of Neurology, Necmettin Erbakan University, School of Medicine, Konya, Turkey., Demir S; Clinic of Neurology, Haydarpasa Sultan Abdulhamid Research and Training Hospital, İstanbul, Turkey., Mısırlı CH; Clinic of Neurology, Saglik Bilimleri University, Haydarpasa Numune Research and Treaning Hospital, İstanbul, Turkey., Küçükoğlu H; Clinic of Neurology, Bakirkoy Research and Training Hospital for Neurologic and Psychiatric Diseases, İstanbul, Turkey., Çınar N; Department of Neurology, Maltepe University, School of Medicine, İstanbul, Turkey., Domaç FM; Clinic of Neurology, Erenkoy Research and Training Hospital for Neurologic and Psychiatric Diseases, İstanbul, Turkey., Öztürk Ş; Department of Neurology, Selcuk University, School of Medicine, Konya, Turkey., Sungur MA; Department of Biostatistics, Duzce University, School of Medicine, Duzce., Yayla V; Clinic of Neurology, Bakirkoy Sadi Konuk Research and Training Hospital, İstanbul, Turkey., Karahan AY; Clinic of Neurology, Beyhekim Government Hospital, Konya., Afşar N; Department of Neurology, Bahcesehir University, School of Medicine, İstanbul, Turkey., Göksu EÖ; Clinic of Neurology, Antalya Research and Treaning Hospital, Antalya, Turkey., Aytaç E; Clinic of Neurology, Ankara Research and Treaning Hospital, Ankara., Yeşilot N; Department of Neurology, Istanbul University, School of Medicine, İstanbul, Turkey., İnce B; Department of Neurology, Istanbul University, Cerrahpasa School of Medicine, İstanbul, Turkey., Yalın OÖ; Clinic of Neurology, Samatya Research and Treaning Hospital, İstanbul, Turkey., Oruç S; Department of Neurology, Kocatepe University, School of Medicine, Afyon, Turkey., Senol MG; Clinic of Neurology, Haydarpasa Sultan Abdulhamid Research and Training Hospital, İstanbul, Turkey., Yılmaz A; Department of Neurology, Mersin University, School of Medicine, Mersin, Turkey., Gökçe M; Department of Neurology, Sutcu Imam University, School of Medicine, Kahramanmaras, Turkey., Küsbeci ÖY; Clinic of Neurology, Bozyaka Education, Research and Treaning Hospital, Izmir, Turkey., Uzuner G; Department of Neurology, Osmangazi University, School of Medicine, Eskisehir, Turkey., Batur Çağlayan HZ; Department of Neurology, Gazi University, School of Medicine, Ankara, Turkey., Açıkgöz M; Department of Neurology, Bulent Ecevit University, School of Medicine, Zonguldak, Turkey., Kurucu H; Department of Neurology, Istanbul University, Cerrahpasa School of Medicine, İstanbul, Turkey., Ozdag F; Clinic of Neurology, Haydarpasa Sultan Abdulhamid Research and Training Hospital, İstanbul, Turkey., Ekmekci H; Department of Neurology, Selcuk University, School of Medicine, Konya, Turkey., Çabalar M; Clinic of Neurology, Bakirkoy Sadi Konuk Research and Training Hospital, İstanbul, Turkey., Yurekli VA; Department of Neurology, Suleyman Demirel University, School of Medicine, Isparta, Turkey., Güneş T; Department of Neurology, Istanbul University, Cerrahpasa School of Medicine, İstanbul, Turkey., Genç H; Department of Neurology, Mersin University, School of Medicine, Mersin, Turkey., Utku U; Department of Neurology, Sutcu Imam University, School of Medicine, Kahramanmaras, Turkey., Şahin Ş; Department of Neurology, Maltepe University, School of Medicine, İstanbul, Turkey., Tokuc FEU; Clinic of Neurology, Antalya Research and Treaning Hospital, Antalya, Turkey., Uzuner N; Department of Neurology, Osmangazi University, School of Medicine, Eskisehir, Turkey., Bektaş H; Clinic of Neurology, Ataturk Research and Treaning Hospital, Ankara, Turkey., Kablan Y; Department of Neurology, Inonu University, School of Medicine, Malatya, Turkey., Göksel BK; Department of Neurology, Baskent University, School of Medicine, Adana, Turkey., Milanlıoğlu A; Department of Neurology, Yuzuncu Yıl University, School of Medicine, Van, Turkey., Örken DN; Clinic of Neurology, Sisli Hamidiye Etfal Research and Treaning Hospital, İstanbul, Turkey., Aluclu U; Department of Neurology, Dicle University, School of Medicine, Diyarbakir, Turkey., Midi İ; Department of Neurology, Marmara University, School of Medicine, İstanbul, Turkey., Çolakoğlu S; Department of Neurology, Mustafa Kemal University, School of Medicine, Hatay, Turkey., Tüfekçi A; Department of Neurology, Recep Tayyip Erdoğan University, School of Medicine, Rize, Turkey., Bakar M; Department of Neurology, Uludağ University, School of Medicine, Bursa, Turkey., Nazlıel B; Department of Neurology, Gazi University, School of Medicine, Ankara, Turkey., Taşçılar N; Department of Neurology, Bulent Ecevit University, School of Medicine, Zonguldak, Turkey., Göksan B; Department of Neurology, Istanbul University, Cerrahpasa School of Medicine, İstanbul, Turkey.
Jazyk: angličtina
Zdroj: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2019 Dec; Vol. 28 (12), pp. 104372. Date of Electronic Publication: 2019 Sep 24.
DOI: 10.1016/j.jstrokecerebrovasdis.2019.104372
Abstrakt: Aim: Systemic lupus erythematosus (SLE) is an unusual risk factor for cerebral venous sinus thrombosis (CVST). As few CVST patients with SLE have been reported, little is known regarding its frequency as an underlying etiology, clinical characteristics, or long-term outcome. We evaluated a large cohort of CVST patients with SLE in a multicenter study of cerebral venous thrombosis, the VENOST study, and their clinical characteristics.
Material and Method: Among the 1144 CVST patients in the VENOST cohort, patients diagnosed with SLE were studied. Their demographic and clinical characteristics, etiological risk factors, venous involvement status, and outcomes were recorded.
Results: In total, 15 (1.31%) of 1144 CVST patients had SLE. The mean age of these patients was 39.9 ± 12.1 years and 13 (86.7%) were female. Presenting symptoms included headache (73.3%), visual field defects (40.0%), and altered consciousness (26.7%). The main sinuses involved were the transverse (60.0%), sagittal (40.0%), and sigmoid (20.0%) sinuses. Parenchymal involvement was not seen in 73.3% of the patients. On the modified Rankin scale, 92.9% of the patients scored 0-1 at the 1-month follow-up and 90.9% scored 0-1 at the 1-year follow-up.
Conclusions: SLE was found in 1.31% of the CVST patients, most frequently in young women. Headache was the most common symptom and the CVST onset was chronic in the majority of cases. The patient outcomes were favorable. CVST should be suspected in SLE patients, even in those with isolated chronic headache symptoms with or without other neurological findings.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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