Perspectives for Ag 2 S NIR-II nanoparticles in biomedicine: from imaging to multifunctionality.

Autor:	Shen Y; Fluorescence Imaging Group, Departamento de Física de Materiales - Facultad de Ciencias, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente 7, Madrid 28049, Spain., Lifante J; Fluorescence Imaging Group, Departamento de Fisiología - Facultad de Medicina, Avda. Arzobispo Morcillo 2, Universidad Autónoma de Madrid, Madrid 28029, Spain and Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Ctra. Colmenar km. 9.100, Madrid 28034, Spain., Ximendes E; Fluorescence Imaging Group, Departamento de Física de Materiales - Facultad de Ciencias, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente 7, Madrid 28049, Spain and Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Ctra. Colmenar km. 9.100, Madrid 28034, Spain., Santos HDA; Grupo de Nano-Fotônica e Imagens, Instituto de Física, Universidade Federal de Alagoas, Maceió-AL 57072-900, Brazil., Ruiz D; IMDEA Nanoscience, Faraday 9, Campus de Cantoblanco, Madrid 28049, Spain., Juárez BH; IMDEA Nanoscience, Faraday 9, Campus de Cantoblanco, Madrid 28049, Spain and Department of Applied Physical Chemistry and Condensed Matter Physics Center (IFIMAC), Universidad Autónoma de Madrid, 28049 Madrid, Spain., Zabala Gutiérrez I; Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Plaza de Ramón y Cajal, s/n, Universidad Complutense de Madrid, Madrid 28040, Spain., Torres Vera V; Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Plaza de Ramón y Cajal, s/n, Universidad Complutense de Madrid, Madrid 28040, Spain., Rubio Retama J; Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Ctra. Colmenar km. 9.100, Madrid 28034, Spain and Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Plaza de Ramón y Cajal, s/n, Universidad Complutense de Madrid, Madrid 28040, Spain., Martín Rodríguez E; Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Ctra. Colmenar km. 9.100, Madrid 28034, Spain and Fluorescence Imaging Group, Departamento de Física Aplicada - Facultad de Ciencias, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente 7, Madrid 28049, Spain., Ortgies DH; Fluorescence Imaging Group, Departamento de Física de Materiales - Facultad de Ciencias, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente 7, Madrid 28049, Spain and Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Ctra. Colmenar km. 9.100, Madrid 28034, Spain., Jaque D; Fluorescence Imaging Group, Departamento de Física de Materiales - Facultad de Ciencias, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente 7, Madrid 28049, Spain and Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Ctra. Colmenar km. 9.100, Madrid 28034, Spain., Benayas A; Department of Physics and CICECO-Aveiro Institute of Materials; University of Aveiro, 3810-193 Aveiro, Portugal. abenayas@ua.pt., Del Rosal B; Centre for Micro-Photonics, Faculty of Science Engineering and Technology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia. bdelrosalrabes@swin.edu.au.
Jazyk:	angličtina
Zdroj:	Nanoscale [Nanoscale] 2019 Nov 07; Vol. 11 (41), pp. 19251-19264. Date of Electronic Publication: 2019 Sep 27.
DOI:	10.1039/c9nr05733a
Abstrakt:	Research on near-infrared (NIR) bioimaging has progressed very quickly in the past few years, as fluorescence imaging is reaching a credible implementation as a preclinical technique. The applications of NIR bioimaging in theranostics have contributed to its increasing impact. This has brought about the development of novel technologies and, simultaneously, of new contrast agents capable of acting as efficient NIR optical probes. Among these probes, Ag 2 S nanoparticles (NPs) have attracted increasing attention due to their temperature-sensitive NIR-II emission, which can be exploited for deep-tissue imaging and thermometry, and their heat delivery capabilities. This multifunctionality makes Ag 2 S NPs ideal candidates for theranostics. This review presents a critical analysis of the synthesis routes, properties and optical features of Ag 2 S NPs. We also discuss the latest and most remarkable achievements enabled by these NPs in preclinical imaging and theranostics, together with a critical assessment of their potential to face forthcoming challenges in biomedicine.
Databáze:	MEDLINE
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