CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways.

Autor: Wein AN; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., McMaster SR; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Takamura S; Department of Immunology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan., Dunbar PR; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Cartwright EK; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Hayward SL; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., McManus DT; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Shimaoka T; Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan., Ueha S; Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan., Tsukui T; Department of Medicine, University of California, San Francisco, San Francisco, CA., Masumoto T; Department of Immunology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan., Kurachi M; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Matsushima K; Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan., Kohlmeier JE; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA jkohlmeier@emory.edu.; Emory-UGA Center of Excellence for Influenza Research and Surveillance, Atlanta, GA.
Jazyk: angličtina
Zdroj: The Journal of experimental medicine [J Exp Med] 2019 Dec 02; Vol. 216 (12), pp. 2748-2762. Date of Electronic Publication: 2019 Sep 26.
DOI: 10.1084/jem.20181308
Abstrakt: Resident memory T cells (T RM cells) are an important first-line defense against respiratory pathogens, but the unique contributions of lung T RM cell populations to protective immunity and the factors that govern their localization to different compartments of the lung are not well understood. Here, we show that airway and interstitial T RM cells have distinct effector functions and that CXCR6 controls the partitioning of T RM cells within the lung by recruiting CD8 T RM cells to the airways. The absence of CXCR6 significantly decreases airway CD8 T RM cells due to altered trafficking of CXCR6 -/- cells within the lung, and not decreased survival in the airways. CXCL16, the ligand for CXCR6, is localized primarily at the respiratory epithelium, and mice lacking CXCL16 also had decreased CD8 T RM cells in the airways. Finally, blocking CXCL16 inhibited the steady-state maintenance of airway T RM cells. Thus, the CXCR6/CXCL16 signaling axis controls the localization of T RM cells to different compartments of the lung and maintains airway T RM cells.
(© 2019 Wein et al.)
Databáze: MEDLINE
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