A cross-sectional comparison between cardiorespiratory fitness, level of lesion and red blood cell distribution width in adults with chronic spinal cord injury.

Autor: Nightingale TE; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Canada; Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, Canada; Department for Health, University of Bath, UK., Bhangu GS; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Canada., Bilzon JLJ; Department for Health, University of Bath, UK., Krassioukov AV; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Canada; Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, Canada; GF Strong Rehabilitation Center, Vancouver Coastal Health, Canada. Electronic address: krassioukov@icord.org.
Jazyk: angličtina
Zdroj: Journal of science and medicine in sport [J Sci Med Sport] 2020 Feb; Vol. 23 (2), pp. 106-111. Date of Electronic Publication: 2019 Aug 21.
DOI: 10.1016/j.jsams.2019.08.015
Abstrakt: Objectives: To assess; (1) differences in red blood cell distribution width between individuals with chronic (>1year), motor-complete cervical (n=21), upper-thoracic (n=27) and thoracolumbar (n=15) spinal cord injury and, (2) associations between red blood cell distribution width and cardiorespiratory fitness.
Design: Prospective multi-center, cross-sectional study.
Methods: Peak oxygen uptake was determined using an upper-body arm-crank exercise test to volitional exhaustion and red blood cell distribution width was measured using an automated hematology system.
Results: There were significant (p<0.009) differences between groups classified by level of injury in absolute and relative peak oxygen uptake, peak power output and red blood cell distribution width. A significant (p<0.001) large negative association (r = -0.524) was found between relative peak oxygen uptake and red blood cell distribution width. Unbiased recursive partitioning, while revealing study site specific differences in red blood cell distribution width, identified homogenous subgroups based specifically on cardiorespiratory fitness irrespective of additional demographic and injury characteristics.
Conclusion: The strong negative association between cardiorespiratory fitness and red blood cell distribution width in individuals with paraplegia parallel those previously observed in non-disabled individuals. Higher red blood cell distribution width values are an independent risk factor for increased cardiovascular mortality, heart failure, and coronary heart disease and may reflect several underlying exacerbated metabolic responses such as oxidative stress and systemic inflammation. These data emphasize the importance of maintaining a high aerobic capacity following spinal cord injury.
(Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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