| Autor: |
Bailey DM, DeGrazia GD, Alexander EJ, Powles RG, Johnson RE, Patrick RA, Heerdt BG, Fairbain ME, Pruden DJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1985 Feb; Vol. 28 (2), pp. 160-4. |
| DOI: |
10.1021/jm00380a002 |
| Abstrakt: |
The syntheses of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids are described. These compounds express potent in vitro inhibition of the human classical complement pathway, and qualitative SAR have been determined. Several of the in vitro active compounds also suppressed the complement dependent reverse passive Arthus reaction (RPAR) in guinea pigs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
