Chronic elevation of glucorticoids late in life generates long lasting changes in physiological state without a life history switch.

Autor: Josserand R; Sorbonne Université, CNRS, iEES Paris, UMR 7618, 4 place Jussieu, F-75005 Paris, France., Haussy C; Sorbonne Université, CNRS, iEES Paris, UMR 7618, 4 place Jussieu, F-75005 Paris, France., Agostini S; Centre de recherche en écologie expérimentale et prédictive (CEREEP-Ecotron IleDeFrance), Ecole normale supérieure, CNRS, PSL Research University, UMS 3194, 78 rue du château, 77140 Saint-Pierre-lès-Nemours, France., Decencière B; Centre de recherche en écologie expérimentale et prédictive (CEREEP-Ecotron IleDeFrance), Ecole normale supérieure, CNRS, PSL Research University, UMS 3194, 78 rue du château, 77140 Saint-Pierre-lès-Nemours, France., Le Galliard JF; Sorbonne Université, CNRS, iEES Paris, UMR 7618, 4 place Jussieu, F-75005 Paris, France; Centre de recherche en écologie expérimentale et prédictive (CEREEP-Ecotron IleDeFrance), Ecole normale supérieure, CNRS, PSL Research University, UMS 3194, 78 rue du château, 77140 Saint-Pierre-lès-Nemours, France., Meylan S; Sorbonne Université, CNRS, iEES Paris, UMR 7618, 4 place Jussieu, F-75005 Paris, France; ESPE de Paris, Sorbonne Université, 10 rue Molitor, 75016 Paris, France. Electronic address: sandrine.meylan@upmc.fr.
Jazyk: angličtina
Zdroj: General and comparative endocrinology [Gen Comp Endocrinol] 2020 Jan 01; Vol. 285, pp. 113288. Date of Electronic Publication: 2019 Sep 23.
DOI: 10.1016/j.ygcen.2019.113288
Abstrakt: Chronic stressors have profound impacts on phenotypes and life history strategies on the short term, but delayed effects of stress experienced late in life remain poorly investigated in wild populations. Here, we used a combined laboratory and field experiment to test if chronic stress late in life has immediate and delayed effects on physiological and demographic traits in the common lizard, Zootoca vivipara. We increased plasma corticosterone levels in adults and yearlings during three weeks of the post-reproductive season. We quantified immediate responses in the laboratory, delayed intra-generational effects in field enclosures one month and one year later during the next reproductive season, and delayed inter-generational effects in the first generation of offspring. Our phenotypic assays included metabolism, immune capacities, lipid metabolism and oxidative stress. Relative to placebos, lizards treated with corticosterone had higher body condition and lower oxidative damages but an increased skin swelling response directly after the manipulation. Delayed responses in field enclosures were of three types. First, we found catch-up growth for body mass such the placebos had similar body conditions one month after the laboratory manipulation. Second, we found persistent differences in oxidative damages during one month but not one year later. Third, during the next reproductive season, corticosterone-treated females had higher levels of plasma triglycerides, whereas corticosterone-treated individuals had a higher skin swelling response. We found no delayed inter-generational effects on demographic traits of offspring. Our study demonstrates the potential for long-lasting physiological consequences of chronic corticosterone enhancement despite no obvious changes in life history.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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